| Embryonic cleavage cycles: how is a mouse like a fly? | |
| | |
MedLine Citation:
|
PMID: 14711435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The evolutionary advent of uterine support of embryonic growth in mammals is relatively recent. Nonetheless, striking differences in the earliest steps of embryogenesis make it difficult to draw parallels even with other chordates. We suggest that use of fertilization as a reference point misaligns the earliest stages and masks parallels that are evident when development is aligned at conserved stages surrounding gastrulation. In externally deposited eggs from representatives of all the major phyla, gastrulation is preceded by specialized extremely rapid cleavage cell cycles. Mammals also exhibit remarkably fast cell cycles in close association with gastrulation, but instead of beginning development with these rapid cycles, the mammalian egg first devotes itself to the production of extraembryonic structures. Previous attempts to identify common features of cleavage cycles focused on post-fertilization divisions of the mammalian egg. We propose that comparison to the rapid peri-gastrulation cycles is more appropriate and suggest that these cycles are related by evolutionary descent to the early cleavage stages of embryos such as those of frog and fly. The deferral of events in mammalian embryogenesis might be due to an evolutionary shift in the timing of fertilization. |
| | |
Authors:
|
Patrick H O'Farrell; Jason Stumpff; Tin Tin Su |
Related Documents
:
|
9661875 - Perturbation of tsg101 protein affects cell cycle progression. 20975695 - Sonic hedgehog controls growth of external genitalia by regulating cell cycle kinetics. 18346885 - Reverse the curse--the role of deubiquitination in cell cycle control. 9563645 - Cell cycle arrest and antitumor activity of pironetin and its derivatives. 3510995 - Considerations in the design of possible cell cycle effective drugs. 10498695 - A glial cell arises from an additional division within the mechanosensory lineage durin... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Review |
Journal Detail:
|
Title: Current biology : CB Volume: 14 ISSN: 0960-9822 ISO Abbreviation: Curr. Biol. Publication Date: 2004 Jan |
Date Detail:
|
Created Date: 2004-01-08 Completed Date: 2004-02-26 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9107782 Medline TA: Curr Biol Country: England |
Other Details:
|
Languages: eng Pagination: R35-45 Citation Subset: IM |
Affiliation:
|
Department Biochemistry and Biophysics, GH-S372C Genentech Hall, UCSF, San Francisco, CA 94143-2200, USA. ofarrell@cgl.uscf.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arthropods / embryology* Body Patterning / physiology Cell Cycle / physiology* Cleavage Stage, Ovum / physiology Evolution* Fertilization / physiology Gastrula / cytology* Models, Biological Vertebrates / embryology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 GM037193-19/GM/NIGMS NIH HHS; R01 GM037193-20/GM/NIGMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Centrosomes: Sfi1p and centrin unravel a structural riddle.
Next Document: Tumors of the conjunctiva and cornea.