| Embryonic cerebellar granule cells are resistant to necrosis induced by homocysteine. | |
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MedLine Citation:
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PMID: 16154637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperhomocysteinemia is a risk factor for a range of neurodegenerative conditions, yet its effects in the developing nervous system have been poorly elucidated. We studied the in vitro response of cerebellar granule neurons (CGCs) to homocysteine. We have shown that embryonic CGCs are resistant to homocysteine-induced neurotoxicity, whilst postnatal CGCs are not. This is the first demonstration of a neuronal population undergoing a developmental switch in their response to homocysteine. Greater understanding of this change may have important implications for both neurodegenerative conditions and neurodevelopmental disorders. |
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Authors:
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Nicola S L Foister; Ceri E Oldreive; John B Mackie; Gayle H Doherty |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-09 |
Journal Detail:
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Title: Brain research. Developmental brain research Volume: 160 ISSN: 0165-3806 ISO Abbreviation: Brain Res. Dev. Brain Res. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-28 Completed Date: 2006-02-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908639 Medline TA: Brain Res Dev Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 85-9 Citation Subset: IM |
Affiliation:
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School of Biology, University of St. Andrews, Bute Medical Buildings, St. Mary's Quad, St. Andrews, Fife KY16 9TS, Scotland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism* Animals Animals, Newborn Cells, Cultured Disease Susceptibility / metabolism, physiopathology Homocysteine / metabolism*, toxicity Hyperhomocysteinemia / complications* Mice Microscopy, Electron, Transmission Necrosis / chemically induced*, metabolism, pathology Neurodegenerative Diseases / etiology, metabolism*, physiopathology Neurons / drug effects, metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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