Document Detail


Embryonic cerebellar granule cells are resistant to necrosis induced by homocysteine.
MedLine Citation:
PMID:  16154637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperhomocysteinemia is a risk factor for a range of neurodegenerative conditions, yet its effects in the developing nervous system have been poorly elucidated. We studied the in vitro response of cerebellar granule neurons (CGCs) to homocysteine. We have shown that embryonic CGCs are resistant to homocysteine-induced neurotoxicity, whilst postnatal CGCs are not. This is the first demonstration of a neuronal population undergoing a developmental switch in their response to homocysteine. Greater understanding of this change may have important implications for both neurodegenerative conditions and neurodevelopmental disorders.
Authors:
Nicola S L Foister; Ceri E Oldreive; John B Mackie; Gayle H Doherty
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-09
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  160     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-28     Completed Date:  2006-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  IM    
Affiliation:
School of Biology, University of St. Andrews, Bute Medical Buildings, St. Mary's Quad, St. Andrews, Fife KY16 9TS, Scotland.
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism*
Animals
Animals, Newborn
Cells, Cultured
Disease Susceptibility / metabolism,  physiopathology
Homocysteine / metabolism*,  toxicity
Hyperhomocysteinemia / complications*
Mice
Microscopy, Electron, Transmission
Necrosis / chemically induced*,  metabolism,  pathology
Neurodegenerative Diseases / etiology,  metabolism*,  physiopathology
Neurons / drug effects,  metabolism*,  pathology
Chemical
Reg. No./Substance:
454-28-4/Homocysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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