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Embryonal Rhabdomyosarcoma of the Uterine Cervix in Adults: A Case Report and Literature Review.
MedLine Citation:
PMID:  23903199     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: We report a case of cervical rhabdomyosarcoma in an adult and review of literature.
MATERIALS AND METHODS: A 44-year-old, premenopausal, white woman, complained of vaginal bleeding for 2 months. The gynecological examination showed a cervical polyp protruding from the vagina. The polyp was partially removed by polypectomy. Pathological examination was diagnostic for embryonal rhabdomyosarcoma-botryoid type-of the cervix. Radical class II hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and pelvic lymphadenectomy were performed. Adjuvant multidrug chemotherapy (vincristine, doxorubicin, ifosfamide, and etoposide) plus external beam radiotherapy were administered. Forty-six months after diagnosis, the patient is disease free.
RESULTS: Here, we report a new case and a literature review of a fairly rare cancer, rhabdomyosarcoma of the cervix in an adult. Pathological features and treatment with an aggressive multimodal approach (radical surgery followed by multidrug adjuvant chemotherapy and radiotherapy) are reported. Good treatment-tolerance and optimal results were achieved.
CONCLUSIONS: Every effort should be done during both the diagnostic and therapeutic phase to offer these patients the best chance of survival. Further studies on best approach, chemotherapeutic protocols, and outcome in adults are warranted.
Authors:
Antonino Ditto; Fabio Martinelli; Marialuisa Carcangiu; Eugenio Solima; Karla Jeanette Amaya de Carrillo; Roberta Sanfilippo; Edward Haeusler; Francesco Raspagliesi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-30
Journal Detail:
Title:  Journal of lower genital tract disease     Volume:  -     ISSN:  1526-0976     ISO Abbreviation:  J Low Genit Tract Dis     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-8-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9704963     Medline TA:  J Low Genit Tract Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departments of 1Gynecologic Oncology, 2Pathology, 3Medical Oncology-Adult Sarcoma, and 4Anesthesiology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
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