Document Detail


Embryology and epidemiology of cleft lip and palate.
MedLine Citation:
PMID:  17366840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Craniofacial anomalies, in particular cleft lip and palate, are major human birth defects with a worldwide frequency of 1 in 700 and substantial clinical impact. This article reviews the embryology of the face, lip, and palate to enhance the understanding of the pathogenesis of these lesions, with particular attention to the period of susceptibility during gestation, complexity, and the factors that may influence their development. It includes an overview of the prevalence and environmental and genetic causes of cleft lip-with or without cleft palate- and cleft palate.
Authors:
N Bernheim; M Georges; C Malevez; A De Mey; A Mansbach
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  B-ENT     Volume:  2 Suppl 4     ISSN:  1781-782X     ISO Abbreviation:  B-ENT     Publication Date:  2006  
Date Detail:
Created Date:  2007-03-19     Completed Date:  2007-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247842     Medline TA:  B-ENT     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  11-9     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, The Cleft Lip and Palate Team, Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium. nathalie.bernheim@huderf.be
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MeSH Terms
Descriptor/Qualifier:
Cleft Lip / embryology*,  epidemiology,  genetics
Cleft Palate / embryology*,  epidemiology,  genetics
Disease Susceptibility
Embryonic Development
Face / embryology
Humans
Lip / embryology
Palate / embryology
Prevalence
Risk Factors

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