Document Detail


Embryogenesis of triple neural tube defects: sonic hedgehog-a key?
MedLine Citation:
PMID:  21292070     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Neural tube closure is a complex spatio-temporal process. Multiple neural tube defects (NTDs) in a single patient are extremely rare. Only a few cases of multiple NTDs have been reported in the world literature, including less than 20 cases of double NTDs and 3 cases of triple NTDs. We report a fourth case of triple NTDs and review the literature regarding the embryogenesis. An effort is made to understand the theories of neural tube closure in light of recent advances in molecular biology and identification of the signaling pathways involved.
Authors:
Santosh Kumar Mahalik; Dhananjay Vaze; Toijam Soni Lyngdoh; Manoj Kumar Tewari; Kannan Laksmi Narasimhan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  46     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e5-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
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