Document Detail


Embryo freezing to prevent ovarian hyperstimulation syndrome.
MedLine Citation:
PMID:  11155959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the primary goals of ART is to achieve some degree of supraphysiologic ovarian stimulation. Too vigorous a response can lead to ovarian hyperstimulation syndrome (OHSS), which is potentially life threatening. The incidence of severe OHSS is low, yet global proliferation of ART suggests that the absolute number of cases will be increasing. The clinical course of OHSS is more severe in patients who conceive. Should gonadotropin therapy induce too great a response, OHSS can best be prevented via cycle cancellation and withholding HCG. An alternative, which would not forfeit oocyte retrieval, is to perform elective cryopreservation of all resulting pre-embryos. This requires a strategy to identify patients at risk accurately. Several centers have bypassed fresh embryo transfer to lessen the risk of OHSS. By consensus it appears that this approach reduces but does not eliminate the risk of severe OHSS. Chances of pregnancy are excellent in subsequent cryo thaw transfers.
Authors:
J T Queenan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  169     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-11     Completed Date:  2001-04-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
Affiliation:
Departmnent of Obstetrics and Gynecology, University of Rochester Medical Centre, Rochester, NY 14642, USA. jtqjrmd@aol.com
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MeSH Terms
Descriptor/Qualifier:
Blastocyst / cytology*
Female
Humans
Ovarian Hyperstimulation Syndrome / etiology,  prevention & control*
Ovulation Induction / adverse effects
Pregnancy
Reproductive Techniques

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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