Document Detail

Embryo fetal Development Studies in Nonhuman Primates.
MedLine Citation:
PMID:  23138904     Owner:  NLM     Status:  In-Data-Review    
Embryo fetal development (EFD) studies in nonhuman primates are frequently conducted in macaques with Macaca fascicularis (cynomolgus monkey, long-tailed macaque, crab-eating macaque) being the most accepted model. EFD studies are also feasible in the marmoset. Due to recent guideline changes (ICH M3(R2) and S6(R1)), EFD studies are largely confined to conventional pharmaceutical compounds rather than biopharmaceuticals. This chapter describes basic study designs and provides working protocols for collecting, processing, and staining fetuses, including collection of amniotic fluid and umbilical cord blood. The chapter also covers the examination and terminology for external, visceral, and skeletal examinations of fetuses. The species covered in this chapter are cynomolgus monkey (long-tailed macaque) and marmoset monkey.
Antje Fuchs; Eberhard Buse; Gerhard F Weinbauer
Related Documents :
17027464 - Effect of transport and competition on ligand binding.
23488974 - Cluster based svr-qsar modelling for hts records: an implementation for anticancer lead...
23185344 - Capital growth paths of the neoclassical growth model.
24519334 - Evaluation of a kinetic model for computer simulation of growth and fermentation by sch...
19163244 - Comparison of filtering and classification techniques of electroencephalography for bra...
20330404 - Development of the standard iso 7779 3rd edition: revised and new contents.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  947     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169-83     Citation Subset:  IM    
Covance Laboratories GmbH, Muenster, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Teratology studies in the minipig.
Next Document:  The enhanced pre- and postnatal development study for monoclonal antibodies.