Document Detail

Embryo cryopreservation at the pronuclear stage and efficient embryo use optimizes the chance for a liveborn infant from a single oocyte retrieval.
MedLine Citation:
PMID:  10731539     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate the potential for a liveborn in our program achieved through either fresh or frozen embryos derived from a single oocyte retrieval.
DESIGN: Retrospective analysis.
SETTING: A tertiary referral reproductive medicine unit.
PATIENT(S): All consecutive patients undergoing oocyte retrieval from January 1, 1996, to June 30, 1997.
INTERVENTION(S): All couples undergoing IVF-ET at our center are counseled about a specific embryo transfer number after oocyte retrieval based on demographic and historical factors. Only this specified number of embryos is retained in culture. All normally fertilized (2PN) oocytes exceeding this number are immediately cryopreserved at the pronuclear stage. For couples who do not conceive after fresh embryo transfers, frozen embryo transfers are subsequently performed by usually thawing only the number of embryos intended for transfer, thereby conserving remaining embryos for further potential frozen embryo cycles.
MAIN OUTCOME MEASURE(S): Liveborn delivery per oocyte retrieval.39.0 years were 61.2%, 59.7%, and 18.5%, respectively.
CONCLUSION(S): For women <39 years of age, the efficient use of embryo cryopreservation at the pronuclear stage and economical embryo utilization policies results in cumulative chances for a liveborn exceeding 60%.
M A Damario; D G Hammitt; D R Session; D A Dumesic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  73     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-21     Completed Date:  2000-04-21     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  767-73     Citation Subset:  IM    
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MeSH Terms
Birth Rate
Cryopreservation / methods*
Embryo Transfer
Fertilization in Vitro
Infertility / therapy
Oocytes / physiology*
Pregnancy, Multiple
Reproductive Techniques*
Retrospective Studies
Comment In:
Fertil Steril. 2000 Sep;74(3):613-4   [PMID:  11032469 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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