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Embozene(TM) microspheres induced non-reperfused myocardial infarction in an experimental swine model.
MedLine Citation:
PMID:  22431438     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To develop an MRI compatible, percutaneous technique for the generation of non-reperfused myocardial infarct (MI). BACKGROUND: Modeling non-treated MI has major importance in the development and preclinical testing of new therapeutic strategies for patients missing the time window suitable for revascularization following MI. METHODS: In 31 male swine, non-reperfused MI was generated by permanent occlusion of either the LAD or LCX coronary artery using 900µm Embozene(TM) microspheres. Animals were monitored for 90 minutes post occlusion. Surviving animals were followed up for 2 (n=6), 4 (n=6), 14 (n=6) or 56 (n=6) days. At the end of the planned study session, contrast enhanced MRI, triphenyl-tetrazolium-chloride staining and microscopic histopathology were carried out. RESULTS: The mortality rate in this study was 22.6%. Intraoperative arrhythmias occurred in 14 cases: premature ventricular complexes with (5) or without (3) ventricular tachycardia, 2(nd) degree atrio-ventricular block (1), and ventricular fibrillation (6). MRI, TTC, and histology confirmed the existence of MI in every case. Macroscopic pathology showed that the microspheres caused a practically total occlusion at the epicardial level of the coronary artery. Multiple infarcts were detected in one case, probably due to unintentional reflux of the microspheres. Microspheres retained in the coronary arteries did not cause any MRI artifact. CONCLUSIONS: The generation of non-reperfused MI is feasible by percutaneous injection of Embozene(TM) into the coronary artery system. The MI model thus obtained is suitable for the purposes of MRI experiments. © 2012 Wiley Periodicals, Inc.
Authors:
Akos Varga-Szemes; Pal Kiss; Brigitta C Brott; Dezhi Wang; Tamas Simor; Gabriel A Elgavish
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-19
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  -     ISSN:  1522-726X     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA; Elgavish Paramagnetics Inc., Birmingham, Alabama, USA; Heart Institute, Faculty of Medicine, University of Pecs, Hungary.
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