Document Detail

Embolization for hemoptysis in chronic thromboembolic pulmonary hypertension: report of two cases and a review of the literature.
MedLine Citation:
PMID:  17086459     Owner:  NLM     Status:  MEDLINE    
Hemoptysis is a known complication in patients with bronchial artery hypertrophy due to a variety of chronic pulmonary disorders. Bronchial artery hypertrophy is observed in most patients with chronic thromboembolic pulmonary hypertension (CTEPH), but surprisingly little is known about the incidence of hemoptysis in these patients. In this paper, we report on 2 patients with CTEPH and recurrent severe hemoptysis, who were treated by bronchial artery embolization. One patient recovered and 1 patient died as a consequence of the bleeding. A systematic review revealed 21 studies on the underlying pathology in 1,844 patients with moderate to severe hemoptysis. CTEPH was reported to be the cause of bleeding in 0.1% (n = 2), pulmonary arterial hypertension without chronic thromboembolic disease in 0.2% (n = 4), and acute pulmonary embolism in 0.7% (n = 12) of the patients. In contrast to this, 5 patients (6%) in our own series of 79 CTEPH patients suffered from moderate to severe hemoptysis requiring medical intervention. Severe hemoptysis appears to be an uncommon, but possibly underreported, life-threatening complication in CTEPH patients. As most CTEPH patients require life-long anticoagulants a therapeutic dilemma may ensue. Therefore, we propose that even mild hemoptysis in CTEPH patients warrants prompt evaluation, and treatment by embolization should be offered as first choice in CTEPH patients.
Herre J Reesink; Otto M van Delden; Jaap J Kloek; Henk M Jansen; Jim A Reekers; Paul Bresser
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  30     ISSN:  0174-1551     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  136-9     Citation Subset:  IM    
Department of Pulmonology, F5-144, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands.
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MeSH Terms
Angiography, Digital Subtraction / methods
Chronic Disease
Contrast Media / administration & dosage
Embolization, Therapeutic / methods*
Fatal Outcome
Hemoptysis / etiology,  therapy*
Hypertension, Pulmonary / complications,  therapy*
Pulmonary Artery / radiography
Pulmonary Embolism / complications,  therapy*
Radiographic Image Enhancement / methods
Severity of Illness Index
Tomography, X-Ray Computed
Treatment Outcome
Reg. No./Substance:
0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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