Document Detail

Embolic stroke following thrombolytic therapy for myocardial infarction in a patient with preexisting ventricular thrombi.
MedLine Citation:
PMID:  7831707     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Dislodging of preexisting cardiac thrombi has been a reported but unconfirmed cause of embolic strokes after thrombolytic therapy for myocardial infarction. CASE DESCRIPTION: An 82-year-old woman was admitted with congestive heart failure. Initial echocardiogram demonstrated ventricular thrombi. Three days later she experienced an inferior wall myocardial infarction, and intravenous streptokinase was administered. Six hours later she abruptly developed a global aphasia with a dense right hemiparesis. Repeat echocardiogram did not show any thrombus. CONCLUSIONS: Thrombolytic therapy may have caused embolization of ventricular thrombi. Cardiac conditions that predispose to embolic strokes are not established contraindications to thrombolytic therapy. The potential for thrombolytic therapy to produce embolization in patients with preexisting cardiac mural thrombi should be evaluated.
R E Bautista
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  26     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-02-22     Completed Date:  1995-02-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  324-5     Citation Subset:  IM    
Department of Neurology, Washington University, St Louis, Mo.
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MeSH Terms
Aged, 80 and over
Heart Diseases / complications*
Heart Ventricles
Intracranial Embolism and Thrombosis / etiology*
Myocardial Infarction / complications,  drug therapy
Streptokinase / adverse effects*
Thrombolytic Therapy / adverse effects*
Thrombosis / complications*
Reg. No./Substance:
EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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