Document Detail

Embolic stroke associated with injection of buprenorphine tablets.
MedLine Citation:
PMID:  19752455     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Drug users who crush, dissolve, and inject buprenorphine tablets parenterally may be at risk of severe thromboembolic complications or death. We describe patients with neurologic complications after injecting buprenorphine tablets. METHODS: Brain MRI including diffusion-weighted imaging (DWI) in patients admitted to the neurologic department after injecting buprenorphine tablets were reviewed. RESULTS: Seven men had neurologic complications after buprenorphine tablet injection. In 5 patients, multiple small scattered hyperintense lesions were detected on DWI in the cortex, white matter, and basal ganglia of the cerebral hemisphere; one patient had a single small lesion. The side of MRI abnormality corresponded to the side of needle marks on the neck except in one patient who had bilateral injections. One patient, who denied injecting into the neck, had DWI abnormalities in the middle cerebral artery territory on one side and occlusion of the ipsilateral internal carotid artery. CONCLUSIONS: Buprenorphine tablets can be intentionally or inadvertently injected into the carotid artery, causing a characteristic appearance on diffusion-weighted imaging, consistent with embolic cerebral infarction.
C C Tchoyoson Lim; Sze Haur Lee; Yee-Choon Wong; Francis Hui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  73     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-15     Completed Date:  2009-09-28     Revised Date:  2010-03-22    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  876-9     Citation Subset:  AIM; IM    
Department of Neuroradiology, National Neuroscience Institute, Singapore, 11 Jalan Tan Tock Seng, Singapore 308433.
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MeSH Terms
Brain Ischemia / diagnosis,  pathology
Buprenorphine* / administration & dosage,  adverse effects
Drug Users
Injections / adverse effects*
Magnetic Resonance Imaging
Middle Aged
Narcotics* / administration & dosage,  adverse effects
Stroke / etiology*,  pathology
Thromboembolism / etiology*
Reg. No./Substance:
0/Narcotics; 52485-79-7/Buprenorphine
Comment In:
Neurology. 2010 Mar 9;74(10):863; author reply 863-4   [PMID:  20211913 ]

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