| Embolic infarction followed by serial bone SPECT and MR fusion images--the door to SPECT/MR-. | |
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MedLine Citation:
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PMID: 20847535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We recently experienced a case of cerebral infarction incidentally found by whole body bone scintigraphy for the detection of bone metastasis from renal cell carcinoma. Additional bone SPECT and brain MR fusion images clearly demonstrated the wedge-shaped uptake of tracer corresponded to the abnormal intensity reflecting subacute cerebral infarction. Follow-up bone scan and fused images with MRI showed complete resolution of the abnormal uptake in chronic phase. A breakdown in the normal blood-brain barrier results in abnormal ionic calcium flux into the cells following altered cell membrane integrity leading to precipitation of calcium salts which eventually binds to bone imaging tracer such as (99m)Tc-methylene diphosphonate. That is, increased accumulation of bone seeking agents represents lethal cell death. The recent development of software and hardware has enabled the fusion of functional and anatomic images. Image fusion between SPECT with various tracers and MRI is expected to provide clues as to the underlying cause of diseases and to decide our treatment planning in the near future. |
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Authors:
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Tetsuya Tsujikawa; Tomohito Kamibayashi; Tatsuro Tsuchida; Yusuke Ohkoshi; Hirohiko Kimura |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The journal of medical investigation : JMI Volume: 57 ISSN: 1349-6867 ISO Abbreviation: J. Med. Invest. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9716841 Medline TA: J Med Invest Country: Japan |
Other Details:
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Languages: eng Pagination: 334-7 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Fukui, Fukui, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone Neoplasms
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diagnosis,
radionuclide imaging,
secondary Carcinoma, Renal Cell / diagnosis, radionuclide imaging, secondary Cerebral Infarction / diagnosis*, etiology, radionuclide imaging* Endocarditis / complications Humans Image Processing, Computer-Assisted Incidental Findings Magnetic Resonance Imaging / methods* Male Middle Aged Radiopharmaceuticals / diagnostic use Technetium Tc 99m Medronate / diagnostic use Tomography, Emission-Computed, Single-Photon / methods* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63347-66-0/Technetium Tc 99m Medronate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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