| Elusive control. | |
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MedLine Citation:
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PMID: 8718454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The concept of a single rate-limiting step was proven to be too simplistic for understanding control and regulation of metabolism. Consequently, searches have identified relatively few steps with high control. Here we review a number of such searches and indicate what mechanisms may be responsible for this elusiveness of control. It turns out that this elusiveness of control has itself led to increased understanding of the roles played in metabolic control and regulation of such diverse factors as distributiveness of control, condition dependence, enzyme elasticity, homeostasis, control hierarchies, the input into a pathway, coenzyme sequestration, and redundancy and diversity of control function. |
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Authors:
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H V Westerhoff; B N Kholodenko; M Cascante; K Van Dam |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of bioenergetics and biomembranes Volume: 27 ISSN: 0145-479X ISO Abbreviation: J. Bioenerg. Biomembr. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1996-10-11 Completed Date: 1996-10-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7701859 Medline TA: J Bioenerg Biomembr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 491-7 Citation Subset: IM |
Affiliation:
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Department of Microphysiology, Free University, Amsterdam, Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Enzymes / metabolism Homeostasis* Kinetics Mathematics Metabolism* Models, Biological* |
| Chemical | |
Reg. No./Substance:
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0/Enzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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