Document Detail


Elusive control.
MedLine Citation:
PMID:  8718454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concept of a single rate-limiting step was proven to be too simplistic for understanding control and regulation of metabolism. Consequently, searches have identified relatively few steps with high control. Here we review a number of such searches and indicate what mechanisms may be responsible for this elusiveness of control. It turns out that this elusiveness of control has itself led to increased understanding of the roles played in metabolic control and regulation of such diverse factors as distributiveness of control, condition dependence, enzyme elasticity, homeostasis, control hierarchies, the input into a pathway, coenzyme sequestration, and redundancy and diversity of control function.
Authors:
H V Westerhoff; B N Kholodenko; M Cascante; K Van Dam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of bioenergetics and biomembranes     Volume:  27     ISSN:  0145-479X     ISO Abbreviation:  J. Bioenerg. Biomembr.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-10-11     Completed Date:  1996-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7701859     Medline TA:  J Bioenerg Biomembr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  491-7     Citation Subset:  IM    
Affiliation:
Department of Microphysiology, Free University, Amsterdam, Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Enzymes / metabolism
Homeostasis*
Kinetics
Mathematics
Metabolism*
Models, Biological*
Chemical
Reg. No./Substance:
0/Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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