Document Detail


The elusive magic pill: finding effective therapies for mitochondrial disorders.
MedLine Citation:
PMID:  23355364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of mitochondrial diseases has been estimated at 11.5/100,000 (1:8500) worldwide. In the USA up to 4000 newborns annually are expected to develop a mitochondrial disease. More than 50 million adults in the USA also suffer from diseases in which primary or secondary mitochondrial dysfunction is involved. Mitochondrial dysfunction has been identified in cancer, infertility, diabetes, heart diseases, blindness, deafness, kidney disease, liver disease, stroke, migraine, dwarfism, and resulting from numerous medication toxicities. Mitochondrial dysfunction is also involved in normal aging and age-related neurodegenerative diseases, such as Parkinson and Alzheimer diseases. Yet most treatments available are based on empiric data and clinician experience because of the lack of randomized controlled clinical trials to provide evidence-based treatments for these disorders. Here we explore the current state of research for the treatment of mitochondrial disorders.
Authors:
Amy Goldstein; Lynne A Wolfe
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics     Volume:  10     ISSN:  1878-7479     ISO Abbreviation:  Neurotherapeutics     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-15     Completed Date:  2013-10-24     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  101290381     Medline TA:  Neurotherapeutics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / therapeutic use
Clinical Trials as Topic
Coenzymes / therapeutic use
DNA, Mitochondrial / genetics
Humans
Mitochondrial Diseases / diet therapy,  drug therapy*,  genetics
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Coenzymes; 0/DNA, Mitochondrial
Comments/Corrections

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