| Elucidation of the toxic mechanism of the plasticizers, phthalic acid esters, putative endocrine disrupters: effects of dietary di(2-ethylhexyl)phthalate on the metabolism of tryptophan to niacin in rats. | |
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MedLine Citation:
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PMID: 12036039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have previously reported that the administration of a large amount of di(n-butyl)phthalate (DBP) increased the conversion ratio of tryptophan to niacin in rats. In the present experiment, the effect of di(2-ethylhexyl)phthalate (DEHP) on the conversion ratio and how altering the conversion ratio of tryptophan to niacin depended on the concentration of DEHP were investigated to elucidate the toxic mechanism of phthalic acid esters (PhE). Rats were fed with a diet containing 0%, 0.01%, 0.05%, 0.1%, 0.5%, 1.0%, or 3.0% DEHP for 21 days. To assess the conversion ratio of tryptophan to niacin, urine samples were collected at the last day of the experiment and measured for metabolites on the tryptophan-niacin pathway. The conversion ratio increased with increasing dietary concentration of DEHP above 0.05%; the conversion ratio was about 2% in the control group, whereas it was 28% in the 3.0% DEHP group. It is suggested that the inhibition of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) by DEHP or its metabolites caused this increase in the conversion ratio. We conclude that PhE such as DEHP and DBP disturbed the tryptophan-niacin metabolism. |
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Authors:
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Tsutomu Fukuwatari; Yuko Suzuki; Etsuro Sugimoto; Katsumi Shibata |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 66 ISSN: 0916-8451 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-05-30 Completed Date: 2002-11-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 705-10 Citation Subset: IM |
Affiliation:
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Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Hikone, Japan. fukkie@shc.usp.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Body Weight / drug effects Diethylhexyl Phthalate / administration & dosage, toxicity* Dose-Response Relationship, Drug Energy Intake / drug effects Liver / anatomy & histology, drug effects NAD / metabolism NADP / metabolism Niacin / biosynthesis, urine Organ Size / drug effects Rats Tryptophan / metabolism* |
| Chemical | |
Reg. No./Substance:
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117-81-7/Diethylhexyl Phthalate; 53-59-8/NADP; 53-84-9/NAD; 59-67-6/Niacin; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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