Document Detail


Elucidating the unexplained underperformance syndrome in endurance athletes : the interleukin-6 hypothesis.
MedLine Citation:
PMID:  12895132     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The unexplained underperformance syndrome (UPS), previously known as the overtraining syndrome (OTS), has been defined as a persistent decrement in athletic performance capacity despite 2 weeks of relative rest. It has been proposed that UPS may be caused by excessive cytokine release during and following exercise causing a chronic inflammatory state and 'cytokine sickness'. This article extends that hypothesis by proposing that time-dependent sensitisation could provide a model through which the aetiology of UPS may be explained. In this model, the principal abnormal factors in UPS are an increased production of and/or intolerance to interleukin (IL)-6 during exercise. Strategies to attenuate the IL-6 response to exercise that may also reduce an athlete's susceptibility to UPS are proposed.
Authors:
Paula Robson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Sports medicine (Auckland, N.Z.)     Volume:  33     ISSN:  0112-1642     ISO Abbreviation:  Sports Med     Publication Date:  2003  
Date Detail:
Created Date:  2003-08-04     Completed Date:  2004-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8412297     Medline TA:  Sports Med     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  771-81     Citation Subset:  IM    
Affiliation:
UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Sports Science Institute of South Africa, University of Cape Town, Newlands, South Africa. paularobson@emailacc.com
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MeSH Terms
Descriptor/Qualifier:
Fatigue / blood*,  etiology,  genetics,  psychology
Humans
Interleukin-6 / blood*,  genetics,  physiology
Physical Endurance / physiology
Sports* / physiology,  psychology
Stress, Psychological / blood,  complications
Syndrome
Chemical
Reg. No./Substance:
0/Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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