| Elucidating the mechanisms of atrial flutter cycle length variability using power spectral analysis techniques. | |
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MedLine Citation:
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PMID: 8921796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The mechanism of the small beat-to-beat variations in cycle length of atrial flutter in humans has not been fully explained. We investigated the beat-to-beat control of atrial flutter cycle length using time and frequency analysis techniques. METHODS AND RESULTS: Mean, SD, and power spectra of atrial cycle lengths were calculated from atrial recordings in 28 patients with type I atrial flutter. In control patients, mean and SD values of atrial cycle length were 265 +/- 37 and 4.9 +/- 1.7 ms. Power spectra contained two or three major peaks with 10.6 +/- 9.2% in band 1 (0.0 to 0.18 Hz), 26.7 +/- 15.9% in band 2 (0.18 to 0.6 Hz), and 63.1 +/- 17.7% in band 3 (0.6 to 2.2 Hz). Isoproterenol infusion (n = 8) increased percentage of total power in band 1 (7.1 +/- 5.6% to 25.7 +/- 18.9%, P < .001). Percentage of total power in band 1 was less in patients receiving (n = 5) versus not receiving (n = 18) oral beta-blockers (2.2 +/- 1.9% versus 10.6 +/- 9.2%, P = .003). Standard deviation (2.5 +/- 1.3 versus 4.9 +/- 1.7 ms, P = .009) and total power (2025 +/- 1350 versus 9768 +/- 8874 ms2, P = .005) were less in heart transplant recipients (n = 5) than control patients. Increases in respiratory rate (n = 6) shifted band 2 frequency peak to higher frequencies (0.26 +/- 0.13 to 0.38 +/- 0.18 Hz, P < .05). Atrial cycle length was longer and monophasic action potential duration was shorter during inspiration than during expiration. Band 3 frequency peak was correlated with heart rate (r = .797, P < .0001). CONCLUSIONS: Atrial flutter cycle length variability has an underlying periodic pattern that is detected by spectral analysis. Atrial flutter is modulated on a beat-to-beat basis by an interplay between the autonomic nervous and respiratory systems and the ventricular rate. |
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Authors:
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B S Stambler; K A Ellenbogen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 94 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1996-12-30 Completed Date: 1996-12-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2515-25 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, West Roxbury Veterans Affairs Medical Center, MA 02132, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology Adult Aged Atrial Flutter / physiopathology* Edrophonium / pharmacology Heart / physiopathology* Heart Transplantation Humans Isoproterenol / pharmacology Male Middle Aged Reference Values Respiration Sympathomimetics / pharmacology Vagus Nerve / drug effects, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Sympathomimetics; 312-48-1/Edrophonium; 7683-59-2/Isoproterenol |
| Comments/Corrections | |
Comment In:
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Circulation. 1998 Aug 11;98(6):607-8
[PMID:
9714121
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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