Document Detail

Elucidating biosynthetic pathways for vitamins and cofactors.
MedLine Citation:
PMID:  17898894     Owner:  NLM     Status:  MEDLINE    
The elucidation of the pathways to the water-soluble vitamins and cofactors has provided many biochemical and chemical challenges. This is a reflection both of their complex chemical nature, and the fact that they are often made in small amounts, making detection of the enzyme activities and intermediates difficult. Here we present an orthogonal review of how these challenges have been overcome using a combination of methods, which are often ingenious. We make particular reference to some recent developments in the study of biotin, pantothenate, folate, pyridoxol, cobalamin, thiamine, riboflavin and molybdopterin biosynthesis.
Michael E Webb; Andrée Marquet; Ralf R Mendel; Fabrice Rébeillé; Alison G Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-09-12
Journal Detail:
Title:  Natural product reports     Volume:  24     ISSN:  0265-0568     ISO Abbreviation:  Nat Prod Rep     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-27     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502408     Medline TA:  Nat Prod Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  988-1008     Citation Subset:  IM    
Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK.
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MeSH Terms
Biosynthetic Pathways
Coenzymes / biosynthesis*
Molecular Structure
Vitamins / biosynthesis*
Reg. No./Substance:
0/Coenzymes; 0/Vitamins

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