Document Detail

Eltrombopag before Procedures in Patients with Cirrhosis and Thrombocytopenia.
MedLine Citation:
PMID:  23171114     Owner:  NLM     Status:  In-Data-Review    
To the Editor: Afdhal et al. (Aug. 23 issue)(1) used eltrombopag to increase the platelet count and reduce the need for transfusion in patients with cirrhosis who were undergoing elective invasive procedures. The hemostatic system of patients with cirrhosis is in a "rebalanced" state, owing to concomitant alterations in prohemostatic and antihemostatic pathways.(2),(3) This raises questions regarding the need to increase the platelet count in patients with cirrhosis before invasive procedures.(3) Bleeding events in the eltrombopag and placebo groups were similar, despite a substantial difference between the preprocedural platelet counts in the patients in the two groups; this result . . .
Ton Lisman; Robert J Porte
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  367     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2055-6     Citation Subset:  AIM; IM    
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