Document Detail


Elovl6 promotes nonalcoholic steatohepatitis.
MedLine Citation:
PMID:  22753171     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Hepatic long-chain fatty acid composition is a novel determinant in NASH development, and Elovl6 could be a potential therapeutic target for the prevention and treatment of NASH.
Authors:
Takashi Matsuzaka; Ayaka Atsumi; Rie Matsumori; Tang Nie; Haruna Shinozaki; Noriko Suzuki-Kemuriyama; Motoko Kuba; Yoshimi Nakagawa; Kiyoaki Ishii; Masako Shimada; Kazuto Kobayashi; Shigeru Yatoh; Akimitsu Takahashi; Kazuhiro Takekoshi; Hirohito Sone; Naoya Yahagi; Hiroaki Suzuki; Soichiro Murata; Makoto Nakamuta; Nobuhiro Yamada; Hitoshi Shimano
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  56     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-05     Completed Date:  2013-02-28     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2199-208     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Affiliation:
Department of Endocrinology and Metabolism, University of Tsukuba, Tsukuba, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acetyltransferases / genetics*,  metabolism*
Analysis of Variance
Animals
Blood Glucose / metabolism
Carrier Proteins / metabolism
Cholesterol / metabolism
Diet, Atherogenic
Diet, High-Fat
Disease Models, Animal
Fatty Acids / metabolism*
Fatty Liver / enzymology*,  genetics,  pathology
Gene Expression Profiling*
Hepatocytes / metabolism*
Humans
Inflammasomes / metabolism*
Insulin / blood
Insulin Resistance
Liver / metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Oxidative Stress
Palmitic Acid / metabolism
RNA, Messenger / metabolism
Severity of Illness Index
Transcription Factors / genetics
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Carrier Proteins; 0/Fatty Acids; 0/Inflammasomes; 0/Insulin; 0/NLRP3 protein, human; 0/RNA, Messenger; 0/Transcription Factors; 0/Triglycerides; 57-10-3/Palmitic Acid; 57-88-5/Cholesterol; EC 2.3.1.-/Acetyltransferases; EC 2.3.1.-/fatty acid elongases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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