| Elongation and desaturation of arachidonic and eicosapentaenoic acids in rat liver. Effect of clofibrate feeding. | |
| | |
MedLine Citation:
|
PMID: 1742327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The fatty acid elongation-desaturation ability of 5,8,11,14-eicosatetraenoic (20:4(n-6)) and 5,8,11,14,17-eicosapentaenoic (20:5(n-3)) acids was determined in both liver microsomal and light mitochondrial (rich in peroxisomes) fractions of untreated and clofibrate treated rats. The elongation and the subsequent desaturation steps were performed in the corresponding favorable media. 20:5(n-3) elongation was about 2-times more extensive than that of 20:4(n-6). Clofibrate feeding for 10 days resulted in a marked decrease in the elongation rate with the two substrates, while the delta 4 desaturation rate was increased. There were small differences in the elongation rate between the microsomal and light mitochondrial fractions, however, the relative delta 4 desaturation rate was higher in the light mitochondrial fraction than microsomes. |
| | |
Authors:
|
V Mimouni; E N Christiansen; J P Blond; L Ulmann; J P Poisson; J Bezard |
Related Documents
:
|
15649777 - Fatty acid compositions of collembola: unusually high proportions of c20 polyunsaturate... 14623497 - Membrane polyunsaturated fatty acids and csf cytokines in patients with schizophrenia. 11582857 - The alpha-linolenic acid content of green vegetables commonly available in australia. 581217 - Leukocyte docosahexaenoic acid in juvenile form of ceroid-lipofuscinosis. 18194117 - Pharmacokinetics of mycophenolic acid during the early period after renal transplant. 11348087 - Measurement of cadmium(ii) and calcium(ii) complexation by fulvic acids using 113cd nmr. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biochimica et biophysica acta Volume: 1086 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1991 Nov |
Date Detail:
|
Created Date: 1992-01-16 Completed Date: 1992-01-16 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 349-53 Citation Subset: IM |
Affiliation:
|
Laboratoire de Physiologie Animale et Nutrition, Faculté des Sciences Mirande, Université de Bourgogne, Dijon, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arachidonic Acid / metabolism* Clofibrate / pharmacology* Eicosapentaenoic Acid / metabolism* Liver / drug effects, metabolism* Male Microsomes, Liver / drug effects, metabolism Mitochondria, Liver / drug effects, metabolism Rats |
| Chemical | |
Reg. No./Substance:
|
1553-41-9/Eicosapentaenoic Acid; 506-32-1/Arachidonic Acid; 637-07-0/Clofibrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in fatty acid composition during cell differentiation in the small intestine of suckling pig...
Next Document: The regulation of hepatic lipase and cholesteryl ester transfer protein activity in the cholesterol ...