Document Detail


Ellagic acid protects rat embryos in culture from the embryotoxic effects of N-methyl-N-nitrosourea.
MedLine Citation:
PMID:  1440415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ellagic acid is a naturally occurring plant phenol that has demonstrated anticarcinogenic and antimutagenic activity in several test systems. Given the common proposed etiopathogenic processes of mutagenesis, carcinogenesis, and teratogenesis induced by genotoxic chemicals, the present study was initiated to determine whether ellagic acid would protect rat embryos in culture from the teratogenic effects of N-methyl-N-nitrosourea (MNU). Ellagic acid alone (as used in these experiments; 50 microM in DMSO) was not embryotoxic. Ellagic acid (50 microM) significantly (P less than 0.01) prevented MNU (75 microM)-induced effects including mortality (absence of heart beat), abnormal formation of the cephalic neural tube derivatives, and delayed differentiation as assessed by a morphological scoring system. These embryoprotective effects were dose responsive. Sequential treatment of embryos with ellagic acid followed by MNU in fresh media also was embryoprotective with no diminution of effect. The site at which ellagic acid interrupts the critical teratogenic events induced by MNU is apparently within the embryo and/or placenta. This model of chemical embryoprotection may be useful in determining the role of cell death and/or mutation in the teratogenic mechanism of action of methylating agents.
Authors:
A A Frank; J M Collier; C S Forsyth; Y H Heur; G D Stoner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Teratology     Volume:  46     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-14     Completed Date:  1992-12-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-15     Citation Subset:  IM    
Affiliation:
College of Veterinary Medicine, Oregon State University, Corvallis 97331-4802.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / prevention & control
Animals
Dose-Response Relationship, Drug
Ectogenesis / drug effects*
Ellagic Acid / pharmacology*
Methylnitrosourea / toxicity*
Rats
Rats, Sprague-Dawley / embryology
Teratogens / pharmacology
Grant Support
ID/Acronym/Agency:
RR07079/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Teratogens; 476-66-4/Ellagic Acid; 684-93-5/Methylnitrosourea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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