| Ellagic acid and polyphenolics present in walnut kernels inhibit in vitro human peripheral blood mononuclear cell proliferation and alter cytokine production. | |
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MedLine Citation:
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PMID: 20388139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tree nuts, including walnuts, are important elicitors of food allergy. We examined the ability of walnut kernel polyphenolics and purified ellagic acid (EA) to modulate cytokine production and cellular proliferation from stimulated human peripheral blood mononuclear cells (PBMC). IL-13 and TNF-alpha production decreased while no change was observed in IL-4 production. Paradoxically, EA and the walnut polyphenolics all significantly and dose-dependently inhibited stimulated [phytohemagglutin (PHA), alpha-CD3, and phorbol myristate acetate (PMA)/ionomycin] PBMC proliferation while simultaneously increasing IL-2 production. When added at time 0 min and 2 h, EA dose-dependently inhibited PHA-induced proliferation. However, at 30 min and 1 h, low doses of EA (10 and 1 muM) significantly increased proliferation above that of PHA alone, although higher doses led to inhibition. Our data do not support the hypothesis that walnut polyphenolics skew a cytokine response toward Th2 in an in vitro environment. However, immunomodulatory effects are present, including an inhibition of cellular proliferation despite no decrease in IL-4 or IL-2. |
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Authors:
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Koren C Anderson; Suzanne S Teuber |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1190 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-04-23 Revised Date: 2010-10-19 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 86-96 Citation Subset: IM |
Affiliation:
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School of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Proliferation / drug effects* Cells, Cultured Cytokines / metabolism* Ellagic Acid / chemistry, pharmacology* Flavonoids / chemistry, pharmacology* Humans Interleukin-13 / metabolism Interleukin-2 / metabolism Interleukin-4 / metabolism Juglans / chemistry* Leukocytes, Mononuclear / drug effects* Middle Aged Phenols / chemistry, pharmacology* Phytohemagglutinins / pharmacology Seeds / chemistry* Tumor Necrosis Factor-alpha / metabolism Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Flavonoids; 0/Interleukin-13; 0/Interleukin-2; 0/Phenols; 0/Phytohemagglutinins; 0/Tumor Necrosis Factor-alpha; 0/polyphenols; 207137-56-2/Interleukin-4; 476-66-4/Ellagic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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