| Ellagic acid and its methyl-derivatives inhibit a newly found nitratase activity. | |
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MedLine Citation:
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PMID: 19678852 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have recently shown that low density lipoprotein (LDL) was able to denitrate albumin-bound 3-NO(2)-Tyr residues and to concomitantly release NO(3)(-) through a Ca(2+)-dependent process that has been ascribed to a specific protein structure. A lipophilic food component (gamma-tocopherol), which is easily loaded into LDL has been found to totally inhibit denitrating activity. We presently found that ellagic acid (EA) and its methylated derivatives, 4,4'O-methyl- and 3,3'O-methyl-ellagic acids (MeEA1 and MeEA2, respectively), amphipathic phenolic components of certain fruits and beverages, were also able to inhibit this activity, with a total inhibition for EA and a 60% inhibition for MeEA1 and MeEA2. EA exhibited the highest affinity for protein plasma, whereas a higher affinity of MeEA1 and MeEA2 (with MeEA1 > MeEA2) than EA was found for lipoprotein fractions, suggesting that the inhibition-driving property is protein affinity. As a result of this nitratase-inhibition property EA and its natural metabolite MeEA2 may have a beneficial role in special physiopathological conditions. |
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Authors:
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Claude L Léger; Enrique Torres-Rasgado; Gilles Fouret; Céline Lauret; Marie-Annette Carbonneau |
Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article Date: 2009-08-12 |
Journal Detail:
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Title: Fundamental & clinical pharmacology Volume: 24 ISSN: 1472-8206 ISO Abbreviation: Fundam Clin Pharmacol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-05-12 Completed Date: 2010-08-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710411 Medline TA: Fundam Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 115-9 Citation Subset: IM |
Affiliation:
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EA 2993 Nutrition Humaine et Athérogénèse, Université Montpellier 1, F-34000 Montpellier, France. claude.leger@univmed.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Beverages Blood Proteins / metabolism Ellagic Acid / analogs & derivatives*, chemistry, pharmacology* Fruit / chemistry Humans Lipoproteins / metabolism Oxidoreductases / antagonists & inhibitors* Serum Albumin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/3,3'-O-methylellagic acid; 0/4,4'-O-methylellagic acid; 0/Blood Proteins; 0/Lipoproteins; 0/Serum Albumin; 476-66-4/Ellagic Acid; EC 1.-/Oxidoreductases; EC 1.7.99.-/nitratase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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