Document Detail

Ellagic acid and its methyl-derivatives inhibit a newly found nitratase activity.
MedLine Citation:
PMID:  19678852     Owner:  NLM     Status:  MEDLINE    
We have recently shown that low density lipoprotein (LDL) was able to denitrate albumin-bound 3-NO(2)-Tyr residues and to concomitantly release NO(3)(-) through a Ca(2+)-dependent process that has been ascribed to a specific protein structure. A lipophilic food component (gamma-tocopherol), which is easily loaded into LDL has been found to totally inhibit denitrating activity. We presently found that ellagic acid (EA) and its methylated derivatives, 4,4'O-methyl- and 3,3'O-methyl-ellagic acids (MeEA1 and MeEA2, respectively), amphipathic phenolic components of certain fruits and beverages, were also able to inhibit this activity, with a total inhibition for EA and a 60% inhibition for MeEA1 and MeEA2. EA exhibited the highest affinity for protein plasma, whereas a higher affinity of MeEA1 and MeEA2 (with MeEA1 > MeEA2) than EA was found for lipoprotein fractions, suggesting that the inhibition-driving property is protein affinity. As a result of this nitratase-inhibition property EA and its natural metabolite MeEA2 may have a beneficial role in special physiopathological conditions.
Claude L Léger; Enrique Torres-Rasgado; Gilles Fouret; Céline Lauret; Marie-Annette Carbonneau
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article     Date:  2009-08-12
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  24     ISSN:  1472-8206     ISO Abbreviation:  Fundam Clin Pharmacol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-05-12     Completed Date:  2010-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  115-9     Citation Subset:  IM    
EA 2993 Nutrition Humaine et Athérogénèse, Université Montpellier 1, F-34000 Montpellier, France.
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MeSH Terms
Blood Proteins / metabolism
Ellagic Acid / analogs & derivatives*,  chemistry,  pharmacology*
Fruit / chemistry
Lipoproteins / metabolism
Oxidoreductases / antagonists & inhibitors*
Serum Albumin / metabolism
Reg. No./Substance:
0/3,3'-O-methylellagic acid; 0/4,4'-O-methylellagic acid; 0/Blood Proteins; 0/Lipoproteins; 0/Serum Albumin; 476-66-4/Ellagic Acid; EC 1.-/Oxidoreductases; EC 1.7.99.-/nitratase

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