Document Detail

Ellagic acid, an NF-κB inhibitor, ameliorates renal function in experimental diabetic nephropathy.
MedLine Citation:
PMID:  24877639     Owner:  NLM     Status:  Publisher    
Diabetic nephropathy (DN) is a serious complication confronted by diabetic patients. Available data indicate that the development of DN is linked to inflammation. In this context, nuclear factor-kappa B (NF-κB) has received much attention. Ellagic acid (2,3,7,8-tetrahydroxy-chromeno[5,4,3-cde]chromene-5,10-dione), found abundantly in plant extracts and fruits, possesses numerous medicinal properties. We investigated the nephroprotective effects of oral treatment of ellagic acid in high fat diet/low dose streptozotocin (HFD/STZ)-induced type 2 diabetic Wistar albino rats. Ellagic acid treatment for 16 weeks post induction of diabetes significantly attenuated renal dysfunction and oxidative stress. Ellagic acid significantly inhibited the renal NF-кB activation. Moreover, ellagic acid significantly lowered renal pathology and suppressed transforming growth factor-beta (TGF-β) and fibronectin expressions in renal tissues. Ellagic acid also significantly reduced the serum levels of pro-inflammatory cytokines, interleukin-1beta (IL-1β), IL-6 and tumor necrosis factor-alpha (TNF-α). In cultured rat NRK 52E proximal tubular epithelial cells, ellagic acid treatment inhibited high glucose-induced activation of NF-κB and pro-inflammatory cytokine synthesis. These results suggest that ellagic acid exhibited renal protective effect in diabetic rats partly through antihyperglycemia which was accompanied by attenuation of inflammatory processes via inhibition of NF-κB pathway.
Amjid Ahad; Ajaz Ahmad Ganai; Mohd Mujeeb; Waseem Ahmad Siddiqui
Related Documents :
3884679 - Germicidal persistence of teat dips by modified excised teat procedure.
17093989 - Effective cellulose production by a coculture of gluconacetobacter xylinus and lactobac...
7547149 - Antilisterial activity of thermophilin 347, a bacteriocin produced by streptococcus the...
7064919 - Stability of lactic acid in cerebrospinal fluid specimens.
6207709 - The role of increased lactic acid concentration in neovascularizations.
9839699 - In vitro activation of complement and contact system by lactic acidosis.
8897269 - 3-[(phenylacetyl)amino]-2,6-piperidinedione hydrolysis studies with improved synthesis ...
22805729 - Efficacy of intravenous zoledronic acid in the prevention and treatment of osteoporosis...
23958859 - Chemically activated formation of organic acids in reactions of the criegee intermediat...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-27
Journal Detail:
Title:  Chemico-biological interactions     Volume:  -     ISSN:  1872-7786     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ireland Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hispidin derived from Phellinus linteus affords protection against acrylamide-induced oxidative stre...
Next Document:  Sophoricoside fails the embryo implantation by compromising the uterine endometrial receptivity at i...