| Elimination of vancomycin by continuous arteriovenous hemofiltration. | |
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MedLine Citation:
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PMID: 3255486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Continuous arteriovenous hemofiltration (CAVH) is being used increasingly in pediatric patients with acute renal failure and/or other fluid and electrolyte imbalances. At times, vancomycin may be concurrently given for sepsis therapy. We evaluated the removal of vancomycin by CAVH in a 15-month-old male child with renal failure who was receiving the drug for suspected infection of an arterial catheter. Two separate CAVH treatments were performed with polysulfone membranes. Serum samples and ultrafiltrate outflow (n = 6) were collected over 79 h for vancomycin concentration determination. The mean vancomycin concentration in the ultrafiltrate was 90.4 +/- 5.4% of those of the serum. 0.53-1.11 mg of the drug was removed per hour by CAVH at serum concentrations of 12.4-25.4 mg/l. CAVH vancomycin clearance was 0.039-0.050 liter/h. The CAVH drug clearances accounted for 66.2% of the total vancomycin clearance. CAVH is thus a major route of vancomycin elimination. Dosage adjustment and serum concentration monitoring are necessary in patients undergoing CAVH while receiving vancomycin therapy. |
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Authors:
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A H Lau; E John |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Child nephrology and urology Volume: 9 ISSN: 1012-6694 ISO Abbreviation: Child Nephrol Urol Publication Date: 1988-1989 |
Date Detail:
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Created Date: 1989-10-11 Completed Date: 1989-10-11 Revised Date: 2006-07-19 |
Medline Journal Info:
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Nlm Unique ID: 8910177 Medline TA: Child Nephrol Urol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 232-5 Citation Subset: IM |
Affiliation:
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College of Pharmacy, University of Illinois, Chicago. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Infections
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drug therapy Hemofiltration / instrumentation, methods* Humans Infant Kidney Failure, Acute / blood, metabolism* Male Vancomycin / blood, pharmacokinetics*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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1404-90-6/Vancomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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