Document Detail

Elimination of transformed cells by normal cells: a novel concept for the control of carcinogenesis.
MedLine Citation:
PMID:  8720467     Owner:  NLM     Status:  MEDLINE    
Control of transformed cells by neighbouring normal cells is known since the beginning of transformation studies in vitro. The classical explanation for this phenomenon is based on proliferation inhibition of transformed cells by normal cells. We extend this model by presenting data that show that TGF-beta-treated normal cells can eliminate transformed cells by induction of apoptosis. Both the TGF-beta-induced signal pathway in normal cells, leading to the production of a short-lived apoptosis-inducing factor, as well as the specific interaction of this factor with transformed cells depend on the action of reactive oxygen species. Sensitivity to induction of apoptosis seems to be a common feature associated with the transformed state, independent of the originally transforming principle. Therefore, tumor development should require either interference with the process of elimination or acquisition of resistance against it. We discuss experimental evidence for interfering substances, such as antioxidants, as well as for genetic systems that protect transformed cells from the negative effects of their cellular environment, such as Bcl-2 or papilloma viruses. These findings, as well as the general resistance of exvivo tumor cells against induction of apoptosis are in line with the novel model of control of tumor progression presented by us in this review.
G Bauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Histology and histopathology     Volume:  11     ISSN:  0213-3911     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-09-30     Completed Date:  1996-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  237-55     Citation Subset:  IM    
Abteilung Virologie, Universität Freiburg, FRG.
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MeSH Terms
Apoptosis / drug effects,  physiology
Carcinogens / pharmacology
Cell Transformation, Neoplastic / drug effects,  pathology*
Neoplasms / pathology*,  prevention & control
Transforming Growth Factor beta / pharmacology*
Reg. No./Substance:
0/Carcinogens; 0/Transforming Growth Factor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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