| Elimination of spatial interference in PRESS-localized editing spectroscopy. | |
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MedLine Citation:
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PMID: 17899586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Unambiguous detection of gamma-amino butyric acid (GABA) in the human brain is hindered by low concentration and spectral overlap with other metabolites. The popular MEGA-PRESS (PRESS: point-resolved spectroscopic sequence) method allows spectral separation of GABA from other metabolites, but suffers from a significant signal-to-noise ratio (SNR) reduction due to the 4-compartment artifact. An alternative PRESS localization technique (PRESS+4) was investigated and compared to MEGA-PRESS using numerical simulations, phantom, and in vivo experiments. It was shown that while the MEGA-PRESS method suffers significant signal loss ( approximately equal 20% for the difference spectrum), GABA signal intensity in PRESS+4 is reduced by only 2% compared to the nonlocalized condition at 4T. The improved method retains important features of the popular MEGA-PRESS such as additional water suppression and macromolecular elimination as demonstrated in human brain experiments. This method is not limited to GABA J-difference editing, but can be applied in any PRESS-based experiments. It should prove particularly useful at higher field, where the 4-compartment artifact is especially detrimental. |
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Authors:
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Lana G Kaiser; Karl Young; Gerald B Matson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 58 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-02 Completed Date: 2008-02-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 813-8 Citation Subset: IM |
Affiliation:
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Northern California Institute for Research and Education, San Francisco, California, USA. lana.kaiser@ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Artifacts Brain Chemistry* Humans Magnetic Resonance Spectroscopy / methods* Phantoms, Imaging gamma-Aminobutyric Acid / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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5R01EB766/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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