Document Detail


Elimination of sodium hyaluronate-induced decrease in outflow facility with hyaluronidase.
MedLine Citation:
PMID:  3808583     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of intraocular sodium hyaluronate is complicated by a postoperative rise in intraocular pressure (IOP). The rise in IOP is thought to stem from a "clogging" at the trabecular meshwork by the large molecules of hyaluronate. This study uses serial tonographic measurements in an animal model to document this change in outflow facility. Furthermore, we investigate the ability of the enzyme hyaluronidase to cleave the hyaluronate into smaller molecular weight fragments, in vivo, and thereby eliminate the change in outflow facility. This report demonstrates the potential usefulness of this enzyme and documents the lack of harmful side effects histopathologically.
Authors:
S R Hein; R H Keates; P A Weber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ophthalmic surgery     Volume:  17     ISSN:  0022-023X     ISO Abbreviation:  Ophthalmic Surg     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-03-06     Completed Date:  1987-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0241035     Medline TA:  Ophthalmic Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  731-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Hyaluronic Acid / adverse effects*
Hyaluronoglucosaminidase / therapeutic use*
Intraocular Pressure / drug effects
Molecular Weight
Rabbits
Tonometry, Ocular
Trabecular Meshwork / drug effects*
Chemical
Reg. No./Substance:
9004-61-9/Hyaluronic Acid; EC 3.2.1.35/Hyaluronoglucosaminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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