| Elimination and phase II metabolism of ethanol in camels after intravenous administration. | |
| | |
MedLine Citation:
|
PMID: 20656536 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Ethanol elimination was studied in camels (n=8) after a single bolus intravenous dose of 0.1g/kg bodyweight (BW). Blood samples were then collected at set intervals. Ethanol and ethyl glucuronide (EtG) in blood were analysed by validated static headspace gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry (LC-MS) methods, respectively. Blood-ethanol concentration-time profiles were plotted for each camel and these were evaluated. A simple linear regression model was fitted to the selected data points and the slope of the fitted line was used to estimate the elimination rate, the distribution factor and turnover rate, which were 5.15mg/dL blood/h, 0.55L/kg and 0.028g/h/kg, respectively. Blood EtG concentration-time profiles were also plotted for each camel. The elimination half-life of EtG, estimated by linear regression (using the values obtained after ethanol was completely eliminated) was 2.18h. The theoretical initial blood concentration of EtG (C(0)), obtained by extrapolation to time zero was 23.4μg/dL. The results will be useful in monitoring alcohol doping in camels using either parent drug or metabolite. |
| | |
Authors:
|
Ibrahim A Wasfi; Asmaa M Kamel; Hanan M Saeed; Nasreen A A Saleh; S Wajid; Nawal A Al Katheeri; B A Agha |
Related Documents
:
|
8347376 - Decrease of isoprene concentrations in blood during general anesthesia. 8182496 - Viscoelastic properties of tissue conditioners--influence of ethyl alcohol content and ... 2777156 - A comparison of post-mortem ethanol levels obtained from blood and subdural specimens. 11552146 - Saliva flow rate, amylase activity, and protein and electrolyte concentrations in saliv... 18432586 - Hyperglycemia and the outcome of pediatric cardiac surgery patients requiring peritonea... 2817726 - Intravenous digital subtraction angiography. a criteria of brain death. |
Publication Detail:
|
Type: Journal Article Date: 2010-07-24 |
Journal Detail:
|
Title: Veterinary journal (London, England : 1997) Volume: 189 ISSN: 1532-2971 ISO Abbreviation: Vet. J. Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-06-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9706281 Medline TA: Vet J Country: England |
Other Details:
|
Languages: eng Pagination: 95-9 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Camel Racing Laboratory, Forensic Science Laboratory, PO Box 253, Abu Dhabi, United Arab Emirates. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Description of the first acute bovine diarrhea virus-2 outbreak in Israel.
Next Document: A novel two-chain IGF-II-derived peptide from purified ?-cell granules.