Document Detail

Elimination of metabolic co-operation and the induction of sister chromatid exchanges are not properties common to all promoting or co-carcinogenic agents.
MedLine Citation:
PMID:  7094211     Owner:  NLM     Status:  MEDLINE    
High densities of wild-type, 6-thioguanine sensitive V79 cells reduce the recovery of 6-thioguanine resistant (6TGR) cells when they are co-cultivated. This metabolic co-operation effect has been reported previously to be eliminated by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate and the accompanying enhancement of 6TGR colony recovery has been postulated as a rapid assay for tumour promoters. Elimination of metabolic co-operation, however, does not appear to be a characteristic of either the promoting agents anthralin, iodoacetic acid, oleic acid and delta-haemolysin or the co-carcinogenic/carcinogenic agents griseofulvin, diethylstilboestrol and stilboestrol diproprionate. Moreover, with the exception of stilboestrol diproprionate, none of these agents induce sister chromatid exchanges, but are all, with the exception of delta-haemolysin, associated with limited numerical chromosome changes and in four cases low level aberration induction. None of the agents were mutagenic.
A R Kinsella
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Carcinogenesis     Volume:  3     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1982  
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  499-503     Citation Subset:  IM    
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MeSH Terms
Carcinogens / toxicity*
Cell Communication / drug effects*
Cell Line
Chromosome Aberrations*
Crossing Over, Genetic / drug effects*
Mutagenicity Tests
Phorbol Esters / toxicity
Sister Chromatid Exchange / drug effects*
Reg. No./Substance:
0/Carcinogens; 0/Phorbol Esters

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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