| Elimination of metabolic co-operation and the induction of sister chromatid exchanges are not properties common to all promoting or co-carcinogenic agents. | |
| | |
MedLine Citation:
|
PMID: 7094211 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
High densities of wild-type, 6-thioguanine sensitive V79 cells reduce the recovery of 6-thioguanine resistant (6TGR) cells when they are co-cultivated. This metabolic co-operation effect has been reported previously to be eliminated by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate and the accompanying enhancement of 6TGR colony recovery has been postulated as a rapid assay for tumour promoters. Elimination of metabolic co-operation, however, does not appear to be a characteristic of either the promoting agents anthralin, iodoacetic acid, oleic acid and delta-haemolysin or the co-carcinogenic/carcinogenic agents griseofulvin, diethylstilboestrol and stilboestrol diproprionate. Moreover, with the exception of stilboestrol diproprionate, none of these agents induce sister chromatid exchanges, but are all, with the exception of delta-haemolysin, associated with limited numerical chromosome changes and in four cases low level aberration induction. None of the agents were mutagenic. |
| | |
Authors:
|
A R Kinsella |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Carcinogenesis Volume: 3 ISSN: 0143-3334 ISO Abbreviation: Carcinogenesis Publication Date: 1982 |
Date Detail:
|
Created Date: 1982-09-24 Completed Date: 1982-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 499-503 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carcinogens / toxicity* Cell Communication / drug effects* Cell Line Chromosome Aberrations* Cocarcinogenesis Cricetinae Cricetulus Crossing Over, Genetic / drug effects* Mutagenicity Tests Phorbol Esters / toxicity Sister Chromatid Exchange / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Carcinogens; 0/Phorbol Esters |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultrastructural analysis of pancreatic carcinogenesis. V. Changes in differentiation of acinar cells...
Next Document: Sequential 2-acetylaminofluorene--phenobarbital exposure induces a cytosolic aldehyde dehydrogenase ...