Document Detail


Elimination kinetics of perfluorohexanoic acid in humans and comparison with mouse, rat and monkey.
MedLine Citation:
PMID:  24050716     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Major fluorinated chemical manufacturers have developed new short-chain per- and polyfluorinated substances with more favorable environmental, health and safety profiles. This study provides the first evaluation of the elimination half-life of perfluorohexanoic acid (PFHxA) from the blood of humans. PFHxA biomonitoring data were obtained from a recently published study of professional ski wax technicians. These data were analyzed to provide estimates of the apparent half-life of PFHxA from humans, and comparisons were made with kinetic studies of PFHxA elimination from mice, rats and monkeys. The apparent elimination half-life of PFHxA in highly exposed humans ranged between 14 and 49d with a geomean of 32d. The half-lives of PFHxA in mice, rats, monkeys and humans were proportional to body weight with no differences observed between genders, indicating similar volumes of distribution and similar elimination mechanisms among mammalian species. Compared to long-chain perfluoroalkyl acid analogs, PFHxA is rapidly cleared from biota. The consistent weight-normalized elimination half-lives for PFHxA in mammalian species indicates that results obtained from animal models are suitable for establishment of PFHxA benchmark dose and reference dose hazard endpoints for use in human risk assessments.
Authors:
Mark H Russell; Helena Nilsson; Robert C Buck
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-16
Journal Detail:
Title:  Chemosphere     Volume:  -     ISSN:  1879-1298     ISO Abbreviation:  Chemosphere     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Affiliation:
DuPont Haskell Global Centers for Health and Environmental Sciences, S320/214, P.O. Box 50, Newark, DE, USA. Electronic address: mark.h.russell@dupont.com.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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