Document Detail

Elimination kinetics of isoniazid in the newborn infant.
MedLine Citation:
PMID:  7196317     Owner:  NLM     Status:  MEDLINE    
The elimination of isoniazid was followed in 2 newborn infants who had received the drug transplacentally, and in 1 of the mothers. The half-time for serum elimination for mother No. 1, babies No. 1 and 2 were calculated as 3.0, 7.8 and 19.8 h, respectively. Near equality existed between maternal and newborn serum isoniazid concentrations. Additional studies are required to determine the acetylation capacity of newborns.
J N Miceli; W A Olson; S N Cohen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  2     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1981  
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
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MeSH Terms
Infant, Newborn
Isoniazid / metabolism*,  therapeutic use
Maternal-Fetal Exchange
Pregnancy Complications, Infectious / drug therapy
Tuberculosis / drug therapy
Grant Support
Reg. No./Substance:

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