Document Detail


Elimination kinetics of isoniazid in the newborn infant.
MedLine Citation:
PMID:  7196317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The elimination of isoniazid was followed in 2 newborn infants who had received the drug transplacentally, and in 1 of the mothers. The half-time for serum elimination for mother No. 1, babies No. 1 and 2 were calculated as 3.0, 7.8 and 19.8 h, respectively. Near equality existed between maternal and newborn serum isoniazid concentrations. Additional studies are required to determine the acetylation capacity of newborns.
Authors:
J N Miceli; W A Olson; S N Cohen
Related Documents :
21930667 - Developing nomogram to estimate birth weight from head circumference and mid-upper arm ...
22271567 - Amlodipine fatality in an infant with postmortem blood levels.
22167077 - Visual development of human milk-fed preterm infants provided with extra energy and nut...
23375547 - Should respiratory care in preterm infants include prophylaxis against respiratory sync...
24893127 - Knowledge and beliefs on breastfeeding are not determinants for successful breastfeeding.
9396547 - Extracorporeal life support for nonimmune hydrops fetalis.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  2     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1981  
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Female
Humans
Infant, Newborn
Isoniazid / metabolism*,  therapeutic use
Kinetics
Maternal-Fetal Exchange
Pregnancy
Pregnancy Complications, Infectious / drug therapy
Tuberculosis / drug therapy
Grant Support
ID/Acronym/Agency:
GM-17184/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
54-85-3/Isoniazid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Spermatogenesis in Sciara coprophila. II. Precocious chromosome orientation in meiosis II.
Next Document:  The effect of fetal calf serum on the biology of cultured primary glomerular cells.