Document Detail

Elimination kinetics of ethanol in pregnant women.
MedLine Citation:
PMID:  15135856     Owner:  NLM     Status:  MEDLINE    
To evaluate the pharmacokinetics of ethanol in the early second trimester of pregnancy, ethanol concentrations simultaneously measured in the maternal blood (EtOH-MB) and in the amniotic fluid (EtOH-AF) of six pregnant women were obtained from a previous study in which a single ethanol dose of 300mgkg(-1) body weight was administered orally. For maternal blood ethanol concentration, the kinetic equation was: [Formula: see text] where k(12) and k(21) are, respectively, the rate constant of ethanol transfer from either the central compartment to the peripheral compartment or vice versa; V(max)(EtOH)is the maximal velocity for ethanol oxidation; and K(m)(EtOH) is the concentration at which half of the maximal rate of ethanol elimination is reached. The maximum concentration of EtOH in AF was 60% lower than in MB (P=0.36). However, the AUC(0-3.5h) in AF was only 16% lower than the value for MB (P=0.059). The k(12) (0.20 =/- 0.26 h(-1)) was almost twice faster than k(21) (0, h(-1)). The V(max)(EtOH) was 237.6 +/- 71.5 microgml(-1)h(-1) and K(m)(EtOH) was 3.7 +/- 4.7 microgml(-1). Our results imply that in the early second trimester, ethanol metabolism is fast. However, ethanol clearance from the AF is slower than ethanol clearance in MB. This process is widely variable, and our findings may partially explain the wide variability of ethanol's toxic effects on the fetus.
Alejandro A Nava-Ocampo; Yadira Velázquez-Armenta; James F Brien; Gideon Koren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  18     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-11     Completed Date:  2004-12-22     Revised Date:  2010-01-22    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  613-7     Citation Subset:  IM    
The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ont., Canada.
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MeSH Terms
Acetaldehyde / blood
Amniotic Fluid / metabolism
Area Under Curve
Central Nervous System Depressants / blood,  pharmacokinetics*
Ethanol / blood,  pharmacokinetics*
Pregnancy / metabolism*
Reg. No./Substance:
0/Central Nervous System Depressants; 64-17-5/Ethanol; 75-07-0/Acetaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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