Document Detail

Elimination of inhibitory synapses is a major component of adult ocular dominance plasticity.
MedLine Citation:
PMID:  22542189     Owner:  NLM     Status:  In-Data-Review    
During development, cortical plasticity is associated with the rearrangement of excitatory connections. While these connections become more stable with age, plasticity can still be induced in the adult cortex. Here we provide evidence that structural plasticity of inhibitory synapses onto pyramidal neurons is a major component of plasticity in the adult neocortex. In vivo two-photon imaging was used to monitor the formation and elimination of fluorescently labeled inhibitory structures on pyramidal neurons. We find that ocular dominance plasticity in the adult visual cortex is associated with rapid inhibitory synapse loss, especially of those present on dendritic spines. This occurs not only with monocular deprivation but also with subsequent restoration of binocular vision. We propose that in the adult visual cortex the experience-induced loss of inhibition may effectively strengthen specific visual inputs with limited need for rearranging the excitatory circuitry.
Daniëlle van Versendaal; Rajeev Rajendran; M Hadi Saiepour; Jan Klooster; Laura Smit-Rigter; Jean-Pierre Sommeijer; Chris I De Zeeuw; Sonja B Hofer; J Alexander Heimel; Christiaan N Levelt
Related Documents :
18333969 - Neuronal correlates of perceptual stability during eye movements.
16448249 - Insect detection of small targets moving in visual clutter.
14996429 - Nitric oxide imaging in living neuronal tissues using fluorescent probes.
17169579 - Extra-classical receptive field effects measured in striate cortex with fmri.
10511639 - Residual vision in a subject with damaged visual cortex.
18193039 - Integrating motion and depth via parallel pathways.
9744949 - Dependence on target configuration of express saccade-related activity in the primate s...
8945759 - Analytical characterization of spontaneous activity evolution during hippocampal develo...
9672109 - Volumetric comparison of auditory brain nuclei in ear-tufted araucanas with those in ot...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuron     Volume:  74     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex.
Next Document:  GABAergic inhibition regulates developmental synapse elimination in the cerebellum.