Document Detail


Elimination of inhibitory synapses is a major component of adult ocular dominance plasticity.
MedLine Citation:
PMID:  22542189     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
During development, cortical plasticity is associated with the rearrangement of excitatory connections. While these connections become more stable with age, plasticity can still be induced in the adult cortex. Here we provide evidence that structural plasticity of inhibitory synapses onto pyramidal neurons is a major component of plasticity in the adult neocortex. In vivo two-photon imaging was used to monitor the formation and elimination of fluorescently labeled inhibitory structures on pyramidal neurons. We find that ocular dominance plasticity in the adult visual cortex is associated with rapid inhibitory synapse loss, especially of those present on dendritic spines. This occurs not only with monocular deprivation but also with subsequent restoration of binocular vision. We propose that in the adult visual cortex the experience-induced loss of inhibition may effectively strengthen specific visual inputs with limited need for rearranging the excitatory circuitry.
Authors:
Daniëlle van Versendaal; Rajeev Rajendran; M Hadi Saiepour; Jan Klooster; Laura Smit-Rigter; Jean-Pierre Sommeijer; Chris I De Zeeuw; Sonja B Hofer; J Alexander Heimel; Christiaan N Levelt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuron     Volume:  74     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.
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