Document Detail


Elimination half-life of intravenously administered equine cardiac troponin I in healthy ponies.
MedLine Citation:
PMID:  22432543     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Reasons for performing study: To date, no information is available on the true biological elimination half-life (T(1/2) ) of cardiac troponin I (cTnI) in the equine species. Such data are required to better evaluate the optimal time to acquire the cTnI sample following acute myocardial injury. Objective: To determine the T(1/2) of equine cTnI. Methods: Four healthy ponies received i.v. injections of recombinant equine cTnI. Plasma cTnI concentrations were measured with a point-of-care cTnI analyser at multiple time points after injection. Standard pharmacokinetic analysis was performed to establish the T(1/2) of cTnI. Results: The average T(1/2) of cTnI was determined to be 0.47 h using a single rate elimination model. Conclusion: The elimination of recombinant equine cTnI following i.v. administration is very rapid. Establishing the T(1/2 ) of troponin provides critical information in understanding the clinical application of this cardiac biomarker in equine practice.
Authors:
M S Kraus; B B Kaufer; A Damiani; N Osterrieder; M Rishniw; W Schwark; A R Gelzer; T J Divers
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-20
Journal Detail:
Title:  Equine veterinary journal     Volume:  -     ISSN:  2042-3306     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 EVJ Ltd.
Affiliation:
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, New York, USA Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, New York, USA Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, New York, USA Institut für Virologie, Freie Universität Berlin, Berlin, Germany.
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