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Elimination of erythromycin in milk after intramammary administration in cows with specific mastitis: relation to dose, milking frequency and udder health.
MedLine Citation:
PMID:  20844949     Owner:  NLM     Status:  In-Process    
Elimination of erythromycin in milk following intramammary therapy of specific mastitis in cows was studied. Five cows received therapy in one quarter (G1), and eight in two quarters with five milked twice (G2) and three thrice a day (G3). Dose infused was 300 mg/quarter 12 h × 5 times. The drug concentrations in milk were determined using microbial assay technique with Micrococcus luteus as the test organism. Considerable variations occurred in the excretion of drug; levels for treated quarters being 8.25 to 37.61 μg/ml at first milking that declined rapidly at 24 h and no drug activity was observed beyond 36 h post treatment. In total, about 6-25% of the last infused dose appeared in the milk. Drug crossed to 1/15 quarter (G1), 6/10 quarters (G2) and all the six untreated quarters (G3). Crossover levels were significantly higher in mastitic quarters and for G3 cows, but duration of excretion remained same in all cases. It seems that crossover of erythromycin to untreated quarters is related to the udder health and dose infused.
Baljinder Kumar Bansal; Navdeep S Bajwa; S S Randhawa; Rakesh Ranjan; P S Dhaliwal
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Publication Detail:
Type:  Journal Article     Date:  2010-09-16
Journal Detail:
Title:  Tropical animal health and production     Volume:  43     ISSN:  1573-7438     ISO Abbreviation:  Trop Anim Health Prod     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1277355     Medline TA:  Trop Anim Health Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  323-9     Citation Subset:  IM    
Department of Clinical Veterinary Medicine, Ethics and Jurisprudence, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141 004 Punjab, India.
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