Document Detail

Elimination Reactions of Esters in the Biosynthesis of Polyketides and Ribosomal Peptides.
MedLine Citation:
PMID:  23934669     Owner:  NLM     Status:  Publisher    
Enoyl intermediates are normally obtained through β-elimination of β-hydroxy carbonyl compounds. The OH group is eliminated either directly or is first activated through phosphorylation. Alternative strategies have now been identified: Glutamination or acetylation of a β-hydroxycarbonyl compound followed by β-elimination of an ester was proven to be a key step in the biosynthesis of class I lantipeptide and tetronate antibiotics.
Bartlomiej Krawczyk; Eric F van Herwerden; Herman S Overkleeft; Roderich D Süssmuth
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-9
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  -     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, 10623 Berlin (Germany).
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