| Elimination Reactions of Esters in the Biosynthesis of Polyketides and Ribosomal Peptides. | |
MedLine Citation:
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PMID: 23934669 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Enoyl intermediates are normally obtained through β-elimination of β-hydroxy carbonyl compounds. The OH group is eliminated either directly or is first activated through phosphorylation. Alternative strategies have now been identified: Glutamination or acetylation of a β-hydroxycarbonyl compound followed by β-elimination of an ester was proven to be a key step in the biosynthesis of class I lantipeptide and tetronate antibiotics. |
Authors:
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Bartlomiej Krawczyk; Eric F van Herwerden; Herman S Overkleeft; Roderich D Süssmuth |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-8-9 |
Journal Detail:
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Title: Angewandte Chemie (International ed. in English) Volume: - ISSN: 1521-3773 ISO Abbreviation: Angew. Chem. Int. Ed. Engl. Publication Date: 2013 Aug |
Date Detail:
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Created Date: 2013-8-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, 10623 Berlin (Germany). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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