Document Detail


Eligibility for the surgical trial in intracerebral hemorrhage II study in a population-based cohort.
MedLine Citation:
PMID:  18183500     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: No proven treatments exist for intracerebral hemorrhage (ICH). Carefully selected patients may benefit from surgery, and an international multicenter trial is ongoing. We sought to determine how many patients in a population-based ICH cohort would have been eligible for surgery using the Surgical Trial in Intracerebral Hemorrhage II (STICH II) criteria.
METHODS: We identified all patients aged > or =18 years residing in the five-county Greater Cincinnati region who were hospitalized with first-ever nontraumatic ICH in 2005. STICH II trial criteria were used to determine eligibility for treatment and reasons for exclusion.
RESULTS: During 2005, 286 ICH patients were identified (103 lobar, 126 deep cerebral, 23 brainstem, 28 cerebellar, and 6 IVH). Non-lobar hemorrhages are not eligible for STICH II. Among patients with lobar hemorrhage, 22 had no exclusions. The most common (not mutually exclusive) reasons for exclusion were volume <10 cc or >100 cc (n = 46) and presence of IVH (n = 27). No significant age, gender or racial differences existed between eligible and ineligible patients with lobar ICH. Only one (4.5%) of the 22 STICH II eligible patients in our population had surgery, compared with eight of 81 (9.9%) ineligible lobar ICH patients (P = 0.43). Mortality at 180 days in STICH II eligible patients was 36% vs. 49% for ineligible lobar ICH patients (P = 0.19).
CONCLUSIONS: In this population-based ICH cohort, 7.7% (22 of 286) of ICH patients would have qualified for STICH II enrollment. Other treatment options need to be explored for most ICH patients.
Authors:
Opeolu Adeoye; Daniel Woo; Mary Haverbusch; Haiyang Tao; Padmini Sekar; Charles J Moomaw; Lori Shutter; Dawn Kleindorfer; Brett Kissela; Joseph Broderick; Matthew L Flaherty
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurocritical care     Volume:  9     ISSN:  1541-6933     ISO Abbreviation:  Neurocrit Care     Publication Date:  2008  
Date Detail:
Created Date:  2008-09-23     Completed Date:  2008-12-19     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  101156086     Medline TA:  Neurocrit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  237-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Aged, 80 and over
Cerebral Hemorrhage / mortality*,  surgery*
Cohort Studies
Female
Humans
Male
Middle Aged
Multicenter Studies as Topic / statistics & numerical data
Patient Selection*
Randomized Controlled Trials as Topic / statistics & numerical data*
Stroke / mortality,  surgery
Grant Support
ID/Acronym/Agency:
R-01-NS 36695/NS/NINDS NIH HHS; R01 NS036695/NS/NINDS NIH HHS; R01 NS036695-09/NS/NINDS NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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