Document Detail

Eleven phthalate esters and di(2-ethylhexyl) adipate in one-week duplicate diet samples obtained from hospitals and their estimated daily intake.
MedLine Citation:
PMID:  11358187     Owner:  NLM     Status:  MEDLINE    
Plasticizers in duplicate diet samples obtained over 1 week were analysed in order to estimate daily intake. The phthalate esters were as follows: diethyl, dipropyl, dibutyl, dipentyl, dihexyl, butylbenzyl, dicyclohexyl, di(2-ethylhexyl), dioctyl, diisooctyl (mixture of isomers) and diisononyl (mixture). Di(2-ethylhexyl) adipate was also determined. Homogenized samples of composite meals were extracted with acetonitrile, lipids were removed by extraction into n-hexane and the acetonitrile layer was cleaned using Florisil and Bondesil PSA dual layer column. Phthalates were determined by GC/MS (SIM). Phthalate recovery from the fortified food mixture by this method was 62.5-140.8%. Quality assurance as assessed by three laboratories indicated coefficient of variance in the levels of detected phthalates in same lot samples as below 10%. Detection limits were 0.1-23 ng/g for each phthalate. One-week duplicate diet samples provided by three hospitals in three remote prefectures of Japan were analysed as individual meals. In all 63 samples, DEHP was present at the highest level among all phthalates in the range 10-4400 ng/g. The intake of plasticizers estimated from all samples was 519 microg DEHP/day, 86 microg DEHA/day, 65 microg DINP/day, and 4.7 microg BBP/day. Calculated DEHP in 2-day samples out of 21 days exceeded EU TDI for a person of 50 kg body weight (1850 microg per day). Disposable PVC gloves used during the preparation of meals were suspected as the source of the high DEHP content. One-day intake of the other phthalates and DEHA was below 7% of TDI in all cases. High concentrations of DEHP (5990 ng/g) was found in baby food used in quality assurance work. The source of contamination was the PVC-tube used during production and was effectively reduced by replacing the tube by one made of stainless steel.
Y Tsumura; S Ishimitsu; I Saito; H Sakai; Y Kobayashi; Y Tonogai
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food additives and contaminants     Volume:  18     ISSN:  0265-203X     ISO Abbreviation:  Food Addit Contam     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-18     Completed Date:  2001-12-07     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  England    
Other Details:
Languages:  eng     Pagination:  449-60     Citation Subset:  IM    
National Institute of Health Sciences, Osaka Branch, Japan.
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MeSH Terms
Adipates / analysis*
Food Contamination / analysis*
Food Service, Hospital*
Gas Chromatography-Mass Spectrometry
Infant Food / analysis
Phthalic Acids / administration & dosage,  analysis*
Plasticizers / administration & dosage,  analysis*
Quality Assurance, Health Care
Reg. No./Substance:
0/Adipates; 0/Phthalic Acids; 0/Plasticizers; 2BD76YG9SI/dioctyl adipate; 6O7F7IX66E/phthalic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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