| Elevation of tail skin temperature in ovariectomized rats in relation to menopausal hot flushes. | |
| | |
MedLine Citation:
|
PMID: 10749773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Menopausal hot flushes (HFs), which manifest as an increase in skin temperature, most frequently occur after menopause and cease with the passage of time. We designed this study to elucidate the characteristics of the elevation of tail skin temperature (TST) in ovariectomized (OVX) rats, which is relevant to human symptoms of HFs. First, we measured TST and rectal temperature (RT) and investigated the time course of their changes up to 20 wk after ovariectomy. The TST in OVX rats (28.4 +/- 0.3 degrees C) was significantly (P = 0.0035) elevated from 2 to 7 wk after the ovariectomy compared with that in sham-operated (Sham) rats (27.0 +/- 0.2 degrees C), whereas the RT in OVX rats was elevated from 8 to 20 wk. We next examined the therapeutic effects of estradiol (E(2)) on the elevation of the TST by continuous subcutaneous infusion. E(2) treatment (1.0 microg/day) completely (P = 0.0232) inhibited the elevation of the TST (28.4 +/- 0.3 degrees C for Sham rats, 29.3 +/- 0.3 degrees C for OVX rats, 28.2 +/- 0.4 degrees C for OVX + E(2) 1.0 microg/day rats). These results demonstrated that the elevation of TST in OVX rats was exhibited soon after the estrogen removal and diminished with time and that it was normalized with continuous E(2) replacement. These characteristics are similar to the symptoms of menopausal HFs in women. |
| | |
Authors:
|
T Kobayashi; M Tamura; M Hayashi; Y Katsuura; H Tanabe; T Ohta; K Komoriya |
Related Documents
:
|
15653753 - Ephedrine plus caffeine causes age-dependent cardiovascular responses in fischer 344 rats. 14603373 - Influence of pregnancy on plasma cytokines and the febrile response to intraperitoneal ... 21635263 - Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 278 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2000 Apr |
Date Detail:
|
Created Date: 2000-05-04 Completed Date: 2000-05-04 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: R863-9 Citation Subset: IM |
Affiliation:
|
Pharmacological Research Department, Teijin Institute for Bio-Medical Research, Hino, Tokyo 191-8512, Japan. ts.kobayashi@teijin.co.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Temperature Regulation / drug effects, physiology* Estradiol / pharmacology Female Humans Injections, Subcutaneous Menopause / physiology* Ovariectomy* Rats Rats, Sprague-Dawley Skin Temperature / drug effects, physiology* Specific Pathogen-Free Organisms Tail |
| Chemical | |
Reg. No./Substance:
|
50-28-2/Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glucocorticoid sensitivity of interleukin-1 agonist and antagonist secretion: the effects of age and...
Next Document: Involvement of H(+)-ATPase and carbonic anhydrase in inorganic carbon uptake for endosymbiont photos...