| Elevation of systemic matrix metalloproteinases 2 and 7 and tissue inhibitor of metalloproteinase 2 in patients with a history of Achilles tendon rupture: pilot study. | |
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MedLine Citation:
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PMID: 18628360 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVES: In this study, serum levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) between patients with a history of Achilles tendon rupture and blood donor controls were compared, and their relation to mechanical properties of the tendons during healing were studied. METHODS: More than 3 years after injury, serum levels of MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9 and MMP-13, TIMP-1 and TIMP-2 in eight patients who had Achilles tendon rupture were measured. Twelve blood donors served as controls. During the early phase of healing, the tendon modulus of elasticity was calculated from radiostereometric data and tendon cross-sectional area. RESULTS: Patients with a history of Achilles tendon rupture had increased levels of MMP-2 (median difference 10%, p=0.01), MMP-7 (median difference 15%, p=0.02) and TIMP-2 (median difference 36%, p=0.02), compared with controls. Levels of MMP-7, measured 3 years after injury, correlated inversely to tendon modulus of elasticity (r(s)=20.83, p=0.02) and positively to tendon elongation (r(s)=0.74, p=0.05) during the early phase of healing. There was a trend towards positive correlation between MMP-7 and cross-sectional area during the early phase of healing (r(s)=0.67, p=0.08). CONCLUSIONS: Patients with a history of Achilles tendon rupture appear to have elevated levels of MMP-2, MMP-7 and TIMP-2 in serum. In these pilot data, the view that the MMP-TIMP system is involved in tendinopathy is supported and that disturbances in proteolytic control might be generalised are suggested. |
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Authors:
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B Pasternak; T Schepull; P Eliasson; P Aspenberg |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-15 |
Journal Detail:
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Title: British journal of sports medicine Volume: 44 ISSN: 1473-0480 ISO Abbreviation: Br J Sports Med Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0432520 Medline TA: Br J Sports Med Country: England |
Other Details:
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Languages: eng Pagination: 669-72 Citation Subset: IM |
Affiliation:
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Orthopaedics and Sports Medicine, Department of Clinical and Experimental Medicine, Linköping University, SE-58185 Linköping, Sweden. pasternak@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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