| Elevation of soluble Fas (APO-1, CD95) ligand in natural aging and Werner syndrome. | |
| | |
MedLine Citation:
|
PMID: 20103915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The pathophysiological process of natural human aging has not been studied adequately due to the lack of an appropriate human model. Since recent investigations have suggested that inflammation possibly contributes to the pathogenesis of age-related disorders including atherosclerosis, cancer, and diabetes mellitus, the term "inflammaging," a combination of "inflammation" and "aging," has been coined. Werner syndrome (WS), caused by the loss of function of RecQ3 DNA/RNA helicase, is a typical progeroid syndrome mimicking natural aging, although it is extremely rare outside of Japan. We sought to examine WS patients from an immunological/inflammatory perspective. Sera from 14 mutation-proven WS patients (ages: 33-70 years) and 21 healthy Japanese adults ages 15 to 95 years were examined with ELISA for soluble Fas ligand (sFasL) to compare conventional inflammation markers. With natural aging, a statistically significant correlation (p < 0.0001) was observed in the serum level of sFasL. The sFasL in WS, a level comparable to that in healthy elderly ages 83 to 95 years, had significantly increased (p < 0.05) compared to that in young healthy individuals ages 15 to 70 years. A significant correlation was noted between the serum levels of conventional inflammation markers such as CRP (p < 0.025), ESR (p < 0.024), and WBC count (p < 0.0085). In conclusion, an increased level of serum sFasL in natural aging and WS patients may suggest a common pathophysiological mechanism: inflammation. WS may be a good model for analyzing inflammaging. |
| | |
Authors:
|
Makoto Goto |
Related Documents
:
|
23554545 - Defining adult experiences: perspectives of a diverse sample of young adults. 3621805 - Some demographic and therapeutic features of diabetes mellitus in kuwait. 8714235 - Diagnostic yield of upper gastrointestinal endoscopy in relation to age and gender: a s... 22426565 - Lifestyle of young australian adults with asthma. 16504365 - Quantitative assessment for stimulated saliva flow rate and buffering capacity in relat... 11502475 - Male rodent model of age-related bone loss in men. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Bioscience trends Volume: 2 ISSN: 1881-7823 ISO Abbreviation: Biosci Trends Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2010-01-27 Completed Date: 2010-05-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101502754 Medline TA: Biosci Trends Country: Japan |
Other Details:
|
Languages: eng Pagination: 124-7 Citation Subset: IM |
Affiliation:
|
Division of Anti-Ageing and Longevity Sciences, Department of Clinical Engineering, Faculty of BioMedical Engineering, Toin University of Yokohama, Aoba-ku, Yokohama, Japan. goto@cc.toin.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Aging / blood* Antigens, CD95 / blood* C-Reactive Protein Enzyme-Linked Immunosorbent Assay Female Humans Inflammation / blood Japan Male Middle Aged Werner Syndrome / blood* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD95; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of low-intensity resistance exercise with vascular occlusion on physical function in healthy...
Next Document: Discriminant analysis: A supportive tool for monogenoidean taxonomy.