| Elevation of serum N-terminal pro-brain natriuretic peptide after exercise is an index of myocardial damage or a cytoprotective reflection? | |
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MedLine Citation:
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PMID: 18212715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Recent investigations have suggested the occurrence of transient cardiac dysfunction and reversible myocardial injury in healthy individuals after heavy exercise. Our purpose was to examine if the release of N-terminal pro-brain natriuretic peptide (NT-proBNP) after intense exercise in obviously healthy participants may have cytoprotective and growth-regulating effects or may result from myocardial dysfunction/damage with changes in cTnT as a marker for myocardial cell necrosis during exercise. METHODS: In 43 highly-trained male athletes <35 years old, who were examined immediately after exercising as well as 2 days later, 21 age-matched male patients classified as stage-B according to ACC/AHA guidelines and 35 healthy age-matched males, we evaluated NT-proBNP and 3rd generation's cTnT by electrochemiluminescence immunoassay. All participants underwent a detailed cardiac protocol including echocardiography and electrocardiogram (ECG). RESULTS: In athletes, cTnT consistently remained <0.01 mg/L after exercising as well as after 2 days. NTproBNP immediately after exercising was 58.27+/-19.48 ng/L, without reaching pathological levels, decreasing 2 days later to 22.93+/-10.22 ng/L. Our patients maintained high levels of NTproBNP, as much as a six-fold increase with reference to the levels of our study's control group and with cTnT <0.01 mg/L. In the control group, cTnT and NTproBNP levels were statistically similar with those of the athletes 2 days after exercising. NT-proBNP as a biological marker can reliably discriminate pathological from physiological cardiac hypertrophy. CONCLUSION: A normal plasma concentration of NT-proBNP in consecutive routine check-up, before and after exercise, could minimize the possibility of cardiac dysfunction, whereas persistent elevated plasma concentrations warrant further cardiological evaluation. |
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Authors:
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E Faviou; A Zachari; C Nounopoulos; E Agrafiotis; G Vourli; A Dionyssiou-Asteriou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of sports medicine and physical fitness Volume: 48 ISSN: 0022-4707 ISO Abbreviation: J Sports Med Phys Fitness Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-01-23 Completed Date: 2008-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376337 Medline TA: J Sports Med Phys Fitness Country: Italy |
Other Details:
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Languages: eng Pagination: 90-6 Citation Subset: IM |
Affiliation:
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Department of Clinical Biochemistry, Medical School, University of Athens, Attikon University Hospital, Athens, Greece. efaviou@in.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Cytoprotection* Exercise / physiology* Health Status Indicators Humans Male Myocardium* / metabolism, pathology Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Physical Education and Training Physical Fitness Pilot Projects Sports Medicine Troponin / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Peptide Fragments; 0/Troponin; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
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