Document Detail

Elevation of serum N-terminal pro-brain natriuretic peptide after exercise is an index of myocardial damage or a cytoprotective reflection?
MedLine Citation:
PMID:  18212715     Owner:  NLM     Status:  MEDLINE    
AIM: Recent investigations have suggested the occurrence of transient cardiac dysfunction and reversible myocardial injury in healthy individuals after heavy exercise. Our purpose was to examine if the release of N-terminal pro-brain natriuretic peptide (NT-proBNP) after intense exercise in obviously healthy participants may have cytoprotective and growth-regulating effects or may result from myocardial dysfunction/damage with changes in cTnT as a marker for myocardial cell necrosis during exercise. METHODS: In 43 highly-trained male athletes <35 years old, who were examined immediately after exercising as well as 2 days later, 21 age-matched male patients classified as stage-B according to ACC/AHA guidelines and 35 healthy age-matched males, we evaluated NT-proBNP and 3rd generation's cTnT by electrochemiluminescence immunoassay. All participants underwent a detailed cardiac protocol including echocardiography and electrocardiogram (ECG). RESULTS: In athletes, cTnT consistently remained <0.01 mg/L after exercising as well as after 2 days. NTproBNP immediately after exercising was 58.27+/-19.48 ng/L, without reaching pathological levels, decreasing 2 days later to 22.93+/-10.22 ng/L. Our patients maintained high levels of NTproBNP, as much as a six-fold increase with reference to the levels of our study's control group and with cTnT <0.01 mg/L. In the control group, cTnT and NTproBNP levels were statistically similar with those of the athletes 2 days after exercising. NT-proBNP as a biological marker can reliably discriminate pathological from physiological cardiac hypertrophy. CONCLUSION: A normal plasma concentration of NT-proBNP in consecutive routine check-up, before and after exercise, could minimize the possibility of cardiac dysfunction, whereas persistent elevated plasma concentrations warrant further cardiological evaluation.
E Faviou; A Zachari; C Nounopoulos; E Agrafiotis; G Vourli; A Dionyssiou-Asteriou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of sports medicine and physical fitness     Volume:  48     ISSN:  0022-4707     ISO Abbreviation:  J Sports Med Phys Fitness     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-01-23     Completed Date:  2008-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376337     Medline TA:  J Sports Med Phys Fitness     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  90-6     Citation Subset:  IM    
Department of Clinical Biochemistry, Medical School, University of Athens, Attikon University Hospital, Athens, Greece.
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MeSH Terms
Biological Markers / blood
Exercise / physiology*
Health Status Indicators
Myocardium* / metabolism,  pathology
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Physical Education and Training
Physical Fitness
Pilot Projects
Sports Medicine
Troponin / blood
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/Troponin; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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