Document Detail

Elevation of retinol levels and suppression of alanine aminotransferase activity in the liver of taurine-deficient kittens.
MedLine Citation:
PMID:  2213246     Owner:  NLM     Status:  MEDLINE    
In taurine-deficient cats, the secretion of bile acids is impaired, and this impairment may reduce intestinal uptake of lipophilic vitamins. It was therefore hypothesized that retinol deficiency is involved in the generation of retinal lesions in taurine-deficient kittens. To this end, the concentration of retinol in plasma and liver was determined in taurine-deficient kittens. Further, the effects of taurine deficiency on amino acid concentrations of heart, liver and kidney were investigated. To see whether taurine deficiency adversely affects the liver, hepatic enzymes were measured in plasma and liver of kittens suffering from taurine deficiency. In addition, liver morphology, growth and food intake were studied. Taurine was the only amino acid whose concentration was consistently decreased in plasma of the experimental group. Unexpectedly, retinol level was increased in plasma and liver from taurine-depleted kittens. Several alterations were noted in amino acid concentrations in liver and kidney, but not in heart. Plasma alanine aminotransferase activity was diminished, probably reflecting decreased activity in the liver. Perivenular steatosis was found in both groups. Controls grew linearly, in contrast to deficient animals, which nevertheless consumed more food. The results demonstrate that retinol deficiency is not involved in taurine-deficiency retinopathy. Moreover, taurine is required for linear growth of juvenile cats and for the maintenance of hepatic and renal pools of certain amino acids.
A Lehmann; L Knutsson; I Bosaeus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  120     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-11-21     Completed Date:  1990-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1163-70     Citation Subset:  IM    
Institute of Neurobiology, University of Göteborg, Sweden.
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MeSH Terms
Alanine Transaminase / blood,  metabolism*
Amino Acids / analysis
Animals, Newborn / growth & development
Liver / enzymology,  metabolism*,  pathology
Taurine / administration & dosage*,  metabolism
Vitamin A / blood,  metabolism*
Reg. No./Substance:
0/Amino Acids; 107-35-7/Taurine; 11103-57-4/Vitamin A; EC Transaminase

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