Document Detail

Elevation of pro-inflammatory cytokines, C-reactive protein and cardiac troponin T in chronic renal failure patients on dialysis.
MedLine Citation:
PMID:  17190649     Owner:  NLM     Status:  MEDLINE    
Chronic renal failure (CRF) patients suffer from a chronic inflammation. They are at increased risk of cardiovascular disease. In order to investigate this inflammatory process and cardiovascular risk factors associated with haemodialysis (HD) and peritoneal dialysis (PD), we compared serum/plasma pro-inflammatory cytokines, C-reactive protein (CRP), and cardiac troponin T (cTnT) of 146 CRF patients treated or not treated with PD or HD. Serum cytokines and CRP as well as plasma cTnT were measured by enzyme-linked immunosorbent assay, chemiluminescence immunoassay, and electrochemiluminescence immunoassay, respectively. Results indicated that serum interleukin (IL)-18 concentrations were significantly higher in PD and low creatinine clearance pre-dialysis CRF (LCC) patients than HD patients (both p < 0.05). IL-6 and tumour necrosis factor (TNF)-alpha concentrations were significantly higher in PD patients than LCC patients (both p < 0.01). Serum hsCRP and plasma cTnT in HD were significantly higher than LCC (both p < 0.01). The elevation of pro-inflammatory cytokines should play an important role in the chronic inflammation and increased cardiovascular risk of CRF patients on dialysis. We are evaluating further the diagnostic and prognostic applications of pro-inflammatory cytokines and biochemical inflammatory markers for these patients.
C K Wong; C C Szeto; M H M Chan; C B Leung; P K T Li; C W K Lam
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Immunological investigations     Volume:  36     ISSN:  0882-0139     ISO Abbreviation:  Immunol. Invest.     Publication Date:  2007  
Date Detail:
Created Date:  2006-12-27     Completed Date:  2007-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8504629     Medline TA:  Immunol Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-57     Citation Subset:  IM    
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
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MeSH Terms
C-Reactive Protein / metabolism*
Cross-Sectional Studies
Cytokines / blood
Kidney Failure, Chronic / metabolism*
Middle Aged
Myocardium / metabolism*
Renal Dialysis*
Troponin T / blood*
Reg. No./Substance:
0/Cytokines; 0/Troponin T; 9007-41-4/C-Reactive Protein

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