Document Detail

Elevation of macrophage colony-stimulating factor in amniotic fluid at late stage of normal pregnancy.
MedLine Citation:
PMID:  16451357     Owner:  NLM     Status:  MEDLINE    
PROBLEM: Macrophage colony-stimulating factor (M-CSF) promotes placental growth and maintenance, and regulates trophoblast invasion into the placental bed. We evaluated whether the amniotic fluid M-CSF levels at the late stage of normal pregnancy is altered compared with those at the middle stage. METHOD OF STUDY: This study enrolled 52 subjects experiencing normotensive pregnancies with single fetuses, of whom 26 were women at the late stage (term gravidas) and 26 were women at the middle stage (controls). The average gestational age at entry was 38 weeks of gestation and 17 weeks, respectively. Amniotic fluid was collected from these subjects. Amniotic fluid M-CSF levels were determined by the enzyme-linked immunosorbent assay method then compared between term gravidas and controls. RESULTS: Amniotic fluid M-CSF concentrations were 4815 pg/mL (median) in term gravidas and 3795 pg/mL in controls; the concentrations were significantly higher in term gravidas than in controls. CONCLUSIONS: We demonstrated a significant increase in amniotic fluid M-CSF levels in term gravidas. These results suggest that elevated levels of M-CSF in amniotic fluid have an important immunological function in the maintenance of pregnancy and fetal growth.
Masatoshi Hayashi; Yoshiyasu Hombo; Mitsuei Shibazaki; Atsuko Nakajima; Noriyuki Inaba
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  55     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-02     Completed Date:  2006-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  226-31     Citation Subset:  IM    
Department of Obstetrics and Gynecology, International University of Health and Welfare Atami Hospital, Higashikaigan-cho, Atami-shi, Shizuoka, Japan.
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MeSH Terms
Amniotic Fluid / metabolism*
Gestational Age*
Macrophage Colony-Stimulating Factor / metabolism*
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Reference Values
Reg. No./Substance:
81627-83-0/Macrophage Colony-Stimulating Factor

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