Document Detail


Elevation of individual serum bile acids on exposure to trichloroethylene or alpha-naphthylisothiocyanate.
MedLine Citation:
PMID:  2219116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats were treated with trichloroethylene via intraperitoneal (ip) injection or inhalation, or with ip alpha-naphthylisothiocyanate (ANIT). Serum samples were assayed for indices of liver injury including alanine aminotransferase (ALT), sorbitol dehydrogenase (SDH), alkaline phosphatase (AP), and bilirubin. Liver from some rats was examined for histological appearance. These data were compared to levels of individual serum bile acids (SBA) determined by high-performance liquid chromatography. Trichloroethylene and ANIT, each at their highest dose only, caused elevations in ALT, but not SDH or AP. The highest dose of ANIT also caused elevated serum bilirubin and cholangitis in the liver. SBA were also elevated in response to both trichloroethylene and ANIT, but at doses below those at which other parameters of liver function were increased. For both chemicals, taurocholic acid was the most sensitive of the bile acids assayed, being elevated at the lowest doses tested of 10 mumols/kg for trichloroethylene and 5 mumols/kg for ANIT. As the doses were raised more of the individual bile acids showed increases. On exposure to trichloroethylene via inhalation taurocholic acid was one of two SBA to show elevation. Thus, both trichloroethylene and ANIT cause elevation in SBA at doses well below those which cause an increase in standard indicators of liver dysfunction. This suggests that SBA and perhaps taurocholic acid, in particular, may provide a sensitive tool for studying hepatobiliary effects of chemicals.
Authors:
G F Wang; N H Stacey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  105     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-11-01     Completed Date:  1990-11-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
Affiliation:
National Institute of Occupational Health and Safety, University of Sydney, NSW, Australia.
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MeSH Terms
Descriptor/Qualifier:
1-Naphthylisothiocyanate / toxicity*
Alanine Transaminase / blood
Alkaline Phosphatase / blood
Animals
Bile Acids and Salts / blood*
Bilirubin / blood
Dose-Response Relationship, Drug
L-Iditol 2-Dehydrogenase / blood
Liver / drug effects,  enzymology,  pathology
Male
Rats
Rats, Inbred Strains
Reference Values
Trichloroethylene / toxicity*
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 551-06-4/1-Naphthylisothiocyanate; 635-65-4/Bilirubin; 79-01-6/Trichloroethylene; EC 1.1.1.14/L-Iditol 2-Dehydrogenase; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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