| Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia. | |
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MedLine Citation:
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PMID: 11228496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Elevated amounts of circulating fetal deoxyribonucleic acid in maternal plasma have recently been detected in pregnancies complicated by preeclampsia. We attempted to confirm this finding and simultaneously examined the quantity of maternal circulating deoxyribonucleic acid. STUDY DESIGN: Circulating deoxyribonucleic acid was measured by realtime quantitative polymerase chain reaction in plasma samples obtained from 44 women with preeclampsia and a matched cohort of 53 normotensive pregnant women. RESULTS: We confirmed that circulating fetal deoxyribonucleic acid levels were significantly elevated in pregnancies complicated by preeclampsia (3194.6 vs 332.8 copies/mL; P < .001). We also showed for the first time that circulating maternal deoxyribonucleic acid levels are also elevated (219,023.9 vs 20,235.8 copies/mL; P < .001). The increases in these deoxyribonucleic acid levels corresponded to the severity of the disorder, and values were correlated with each other in pregnancies complicated by preeclampsia (r = 0.556; P < .001) but not normotensive pregnancies (r = 0.046; P = .747). CONCLUSION: The releases of both free fetal and maternal deoxyribonucleic acid were found to be affected in preeclampsia. |
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Authors:
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X Y Zhong; H Laivuori; J C Livingston; O Ylikorkala; B M Sibai; W Holzgreve; S Hahn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 184 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-06 Completed Date: 2001-03-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 414-9 Citation Subset: AIM; IM |
Affiliation:
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Laboratory for Prenatal Medicine, Department of Obstetrics and Gynaecology, University of Basel, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight Blood Pressure Cohort Studies DNA / blood*, chemistry, isolation & purification DNA Primers / chemistry Female Fetus / metabolism Gestational Age Humans Infant, Newborn Male Maternal-Fetal Exchange* Polymerase Chain Reaction Pre-Eclampsia / blood, genetics* Pregnancy Retrospective Studies Statistics, Nonparametric Y Chromosome |
| Grant Support | |
ID/Acronym/Agency:
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N01-HD-4-3202/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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